New Square-Pyramidal Oxovanadium (IV) Complexes Derived from Polydentate Ligand (L¹)  

作　　者：Azza A. Hassoon Najlaa S. Al-Radadi Nagwa Nawar Mohsen M. Mostafa Azza A. Hassoon;Najlaa S. Al-Radadi;Nagwa Nawar;Mohsen M. Mostafa(Chemistry Department, Faculty of Science, Mansoura University, Egypt;Chemistry Department, Faculty of Science, Taibah University, Al-Madinah, Saudia Arabia)

机构地区：[1]Chemistry Department, Faculty of Science, Mansoura University, Egypt [2]Chemistry Department, Faculty of Science, Taibah University, Al-Madinah, Saudia Arabia

出　　处：《Open Journal of Inorganic Chemistry》2016年第1期23-65,共43页无机化学期刊（英文）

摘　　要：New series of oxovanadium (IV) complexes isolated from 2,4,6-tris-(2-pyridyl)-1,3,5-triazine (L¹) are incorporated and portrayed using spectroscopic (IR, UV-Vis, ESR, mass spectrometric), magnetic moment, thermal and cyclic voltammetry measurements. The results demonstrate that L¹ acts in various styles of chelation with [V₃O₃(L¹)(SO₄)₃(EtOH)_1/2(H₂O)_3/2] 1), [VO(L¹)(2,4-pentadionate)]·Cl·4HCl 2), [V₂O₂(L¹)(SO₄)₂(EtOH)_5/2] 3), [V₂O₂(L¹)(SO₄)₂(EtOH)_3/2(H₂O)_1/2] 4), [VO(L¹)SO₄ (H₂O)_3/2]·2.5H₂O 5) and [V₂O₂(L¹)(SO₄)₂(H₂O)]·H₂O 6). The values of magnetic moments and spectral studies suggest a square-pyramidal geometry around the V (IV) ion for all complexes. The molar conductance values suggest that the complexes are non-electrolyte, except the [VO(L¹) (2,4-pentadionate)] Cl·4HCl. Molecular modeling calculates the bond length, bond angle, chemical reactivity, energy components (Kcal/mol) and binding energy (Kcal/mol) for the isolated complexes. The in vitro antibacterial studies of these complexes screened against pathogenic bacteria prove them as growth inhibiting agents. Antitumor activity is carried out in vitro on human mammary gland (breast) MCF-7 and cervical cancer cell-HeLa has shown that [VO(L¹)SO₄(H₂O)_3/2]·2.5 H₂O and [VO(L¹)(2,4-pentadionate)] Cl·4HCl complexes display the highest powerful activity between all of the investigated complexes.New series of oxovanadium (IV) complexes isolated from 2,4,6-tris-(2-pyridyl)-1,3,5-triazine (L¹) are incorporated and portrayed using spectroscopic (IR, UV-Vis, ESR, mass spectrometric), magnetic moment, thermal and cyclic voltammetry measurements. The results demonstrate that L¹ acts in various styles of chelation with [V₃O₃(L¹)(SO₄)₃(EtOH)_1/2(H₂O)_3/2] 1), [VO(L¹)(2,4-pentadionate)]·Cl·4HCl 2), [V₂O₂(L¹)(SO₄)₂(EtOH)_5/2] 3), [V₂O₂(L¹)(SO₄)₂(EtOH)_3/2(H₂O)_1/2] 4), [VO(L¹)SO₄ (H₂O)_3/2]·2.5H₂O 5) and [V₂O₂(L¹)(SO₄)₂(H₂O)]·H₂O 6). The values of magnetic moments and spectral studies suggest a square-pyramidal geometry around the V (IV) ion for all complexes. The molar conductance values suggest that the complexes are non-electrolyte, except the [VO(L¹) (2,4-pentadionate)] Cl·4HCl. Molecular modeling calculates the bond length, bond angle, chemical reactivity, energy components (Kcal/mol) and binding energy (Kcal/mol) for the isolated complexes. The in vitro antibacterial studies of these complexes screened against pathogenic bacteria prove them as growth inhibiting agents. Antitumor activity is carried out in vitro on human mammary gland (breast) MCF-7 and cervical cancer cell-HeLa has shown that [VO(L¹)SO₄(H₂O)_3/2]·2.5 H₂O and [VO(L¹)(2,4-pentadionate)] Cl·4HCl complexes display the highest powerful activity between all of the investigated complexes.

关 键 词：Oxovanadium (IV) Complexes Antimicrobial Activity Cytotoxic Activity Breast Cancer 

分 类 号：O62[理学—有机化学]