Synthesis, Characterization and Biological Activities of Binuclear Metal Complexes of 2-Benzoylpyridine and Phenyl(Pyridin-2-yl) Methanediol Derived from 1-Phenyl-1-(Pyridin-2-yl)-N-(Pyrimidin-2-yl) Methanimine Dihydrate Schiff Base  

作　　者：Francis A. Ngounoue Kamga Evans Ngandung Mainsah Maurice Kuate Peter T. Ndifon Francis A. Ngounoue Kamga;Evans Ngandung Mainsah;Maurice Kuate;Peter T. Ndifon(Department of Inorganic Chemistry, Faculty of Science, University of Yaounde I, Yaoundé, Cameroon;Department of Chemistry, Faculty of Science, University of Buea, Buea, Cameroon)

机构地区：[1]Department of Inorganic Chemistry, Faculty of Science, University of Yaounde I, Yaoundé, Cameroon [2]Department of Chemistry, Faculty of Science, University of Buea, Buea, Cameroon

出　　处：《Open Journal of Inorganic Chemistry》2021年第1期20-42,共23页无机化学期刊（英文）

摘　　要：The Schiff base, 1-phenyl-1-(pyridin-2-yl)-N-(pyrimidin-2-yl)methanimine dihydrate (L₁) has been synthesized by the condensation reaction between 2-aminopyrimidine and 2-benzoylpyridine and characterized using ¹³C-NMR, ¹H-NMR, microanalysis, FT-IR, DEPT-135, HSQC, HMBC, COZY, NOESY. The reaction of 1-phenyl-1-(pyridin-2-yl)-N-(pyrimidin-2-yl)methanimine dihydrate (L₁) with salts of V(IV), Co(II) and Cu(II), however, resulted in the hydrolysis of L₁ to give binuclear metal complexes of 2-benzoylpyridine (L₂) and phenyl(pyridin-2-yl)methanediol (L₃) which were characterized using UV-visible spectroscopy, and TGA. The single crystal x-ray structure determined for the Copper(II) complex revealed that we obtained a compound previously obtained using a different method of synthesis. The Schiff base ligand (L₁) is soluble in methanol, ethanol, DMSO, acetone and DMF. Microanalysis and Spectroscopic studies indicated that binuclear metal complexes were obtained by the coordination of metal ion to 2-benzoylpyridine (L₂) and phenyl(pyridin-2-yl)methanediol (L₃) from the hydrolysis of L₁. Spectroscopic and elemental analysis reveal the formation of square pyramidal complexes of Co(II) and Cu(II) and a square planar complex of V(IV). <i>In vitro</i> antibacterial and antifungal activity against three bacterial strains (<i>Escherichia coli, Klebsiella pneumoniae</i> and <i>Staphylococcus aureus</i>) and three fungal stains (<i>Candida albicans, Candida glabrata and Candida parapsilosis</i>) showed moderate biological activity. Antioxidant studies reveal that only the binuclear Co(II) and oxovanadium(II) complexes are potent to eliminate free radicals.The Schiff base, 1-phenyl-1-(pyridin-2-yl)-N-(pyrimidin-2-yl)methanimine dihydrate (L₁) has been synthesized by the condensation reaction between 2-aminopyrimidine and 2-benzoylpyridine and characterized using ¹³C-NMR, ¹H-NMR, microanalysis, FT-IR, DEPT-135, HSQC, HMBC, COZY, NOESY. The reaction of 1-phenyl-1-(pyridin-2-yl)-N-(pyrimidin-2-yl)methanimine dihydrate (L₁) with salts of V(IV), Co(II) and Cu(II), however, resulted in the hydrolysis of L₁ to give binuclear metal complexes of 2-benzoylpyridine (L₂) and phenyl(pyridin-2-yl)methanediol (L₃) which were characterized using UV-visible spectroscopy, and TGA. The single crystal x-ray structure determined for the Copper(II) complex revealed that we obtained a compound previously obtained using a different method of synthesis. The Schiff base ligand (L₁) is soluble in methanol, ethanol, DMSO, acetone and DMF. Microanalysis and Spectroscopic studies indicated that binuclear metal complexes were obtained by the coordination of metal ion to 2-benzoylpyridine (L₂) and phenyl(pyridin-2-yl)methanediol (L₃) from the hydrolysis of L₁. Spectroscopic and elemental analysis reveal the formation of square pyramidal complexes of Co(II) and Cu(II) and a square planar complex of V(IV). <i>In vitro</i> antibacterial and antifungal activity against three bacterial strains (<i>Escherichia coli, Klebsiella pneumoniae</i> and <i>Staphylococcus aureus</i>) and three fungal stains (<i>Candida albicans, Candida glabrata and Candida parapsilosis</i>) showed moderate biological activity. Antioxidant studies reveal that only the binuclear Co(II) and oxovanadium(II) complexes are potent to eliminate free radicals.

关 键 词：Binuclear Complexes Schiff Base 2-Benzoylpyridine Crystal Structure Antimicrobial Activity Antioxidant Activity 

分 类 号：O62[理学—有机化学]