Characterization and Performance of Magnesium Doped Bioactive Glass Nanoparticles  

作　　者：Anteneh Tilahun Awoke Lingqi Zhu Xinbo Ding Anteneh Tilahun Awoke;Lingqi Zhu;Xinbo Ding(College of Textile Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, China;Department of Textile Engineering, Ethiopian Institutes of Textile and Fashion Technology, Bahir Dar University, Bahir Dar, Ethiopia)

机构地区：[1]College of Textile Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, China [2]Department of Textile Engineering, Ethiopian Institutes of Textile and Fashion Technology, Bahir Dar University, Bahir Dar, Ethiopia

出　　处：《Open Journal of Polymer Chemistry》2024年第2期95-111,共17页高分子化学期刊（英文）

摘　　要：The bioactive glass and related biomaterials have become increasingly popular, and have also attracted the research interest of many researchers in recent years due its special performance and tissue engineering application. In this study, to create a material with a variety of properties Mg doped hollow bioactive glass (Mg-HBG) of 80SiO2-5P2O5-10CaO-5MgO system had been produced by using a sol-gel method. The porous structure nanoparticles were specifically made by employing the cetyltrimethylammonium bromide (CTAB) as a surfactant. Magnesium was selected as a doped material with HBG, because it is the most existing cations in the human body which helps for bone metabolism as well as it has antibacterial property. Based on different investigations resulted nanoparticle with the inclusion of the lower molar fractions magnesium has good tested result. For a drug model vancomycin hydrochloride (VAN) was used in this study and it has also good antibacterial activity effect. These findings help the possibility of using Mg-HBG nanoparticles to treat infectious bone abnormalities by demonstrating their compatibility with antibiotics, drug loading and release behavior.The bioactive glass and related biomaterials have become increasingly popular, and have also attracted the research interest of many researchers in recent years due its special performance and tissue engineering application. In this study, to create a material with a variety of properties Mg doped hollow bioactive glass (Mg-HBG) of 80SiO2-5P2O5-10CaO-5MgO system had been produced by using a sol-gel method. The porous structure nanoparticles were specifically made by employing the cetyltrimethylammonium bromide (CTAB) as a surfactant. Magnesium was selected as a doped material with HBG, because it is the most existing cations in the human body which helps for bone metabolism as well as it has antibacterial property. Based on different investigations resulted nanoparticle with the inclusion of the lower molar fractions magnesium has good tested result. For a drug model vancomycin hydrochloride (VAN) was used in this study and it has also good antibacterial activity effect. These findings help the possibility of using Mg-HBG nanoparticles to treat infectious bone abnormalities by demonstrating their compatibility with antibiotics, drug loading and release behavior.

关 键 词：Tissue Engineering Bioactive Glass Sol-Gel Process Drug Loading and Release 

分 类 号：TB3[一般工业技术—材料科学与工程]