NLRP3 Inflammasome in Relation to Glucose and Lipid Metabolism, and Insulin Resistance in Diabetes and Pre-Diabetes  

作　　者：Shujuan Hu Dang Liu Yinqi Zhang Yiting Ding Bingqing Li Xianwang Wang Shujuan Hu;Dang Liu;Yinqi Zhang;Yiting Ding;Bingqing Li;Xianwang Wang(School of Education and Physical Education, Yangtze University, Jingzhou, China;School of Physical Education and Science, Jishou University, Jishou, China;Department of Biochemistry and Molecular Biology, Center for Molecular Medicine, Health Science Center, Yangtze University, Jingzhou, China;Clinical Laboratory, The Second School of Clinical Medicine and Jingzhou Central Hospital, Yangtze University, Jingzhou, China)

机构地区：[1]School of Education and Physical Education, Yangtze University, Jingzhou, China [2]School of Physical Education and Science, Jishou University, Jishou, China [3]Department of Biochemistry and Molecular Biology, Center for Molecular Medicine, Health Science Center, Yangtze University, Jingzhou, China [4]Clinical Laboratory, The Second School of Clinical Medicine and Jingzhou Central Hospital, Yangtze University, Jingzhou, China

出　　处：《Yangtze Medicine》2023年第1期1-10,共10页长江医药（英文）

摘　　要：Aims: To investigate the relationship among NLRP3 inflammasome, glucose and lipid metabolism, and insulin resistance (IR) in the serum of patients with diabetes and pre-diabetes. Methods: A total of 100 patients with abnormal blood glucose divided into the pre-diabetes mellitus (PDM) group (N = 46) and the type 2 diabetes mellitus (T2DM) group (N = 54). 20 normoglycemic subjects (NG, N = 20) were selected as a control group. The serum levels of glucose and lipid metabolism, IR, and the expression of NLRP3, ASC and Caspase-1 were measured. Besides, the correlations of NLRP3 inflammasome with glucose and lipid metabolism, and IR were analyzed. Results: Compared with the NG group, the levels of NLRP3, ASC, Caspase-1, FBG, HbA₁C, TG, LDL-C, FINs, and HOMA-IR were higher (P β were lower (P P β were seen (P P β. Regression analysis further showed that blood glucose related indexes, FINs, and NLRP3 have made a decisive contribution to IR. Conclusions: Collectively, this evidence suggested that NLRP3 is closely related to glucose and lipid metabolism, and IR, and activated in PDM and T2DM.Aims: To investigate the relationship among NLRP3 inflammasome, glucose and lipid metabolism, and insulin resistance (IR) in the serum of patients with diabetes and pre-diabetes. Methods: A total of 100 patients with abnormal blood glucose divided into the pre-diabetes mellitus (PDM) group (N = 46) and the type 2 diabetes mellitus (T2DM) group (N = 54). 20 normoglycemic subjects (NG, N = 20) were selected as a control group. The serum levels of glucose and lipid metabolism, IR, and the expression of NLRP3, ASC and Caspase-1 were measured. Besides, the correlations of NLRP3 inflammasome with glucose and lipid metabolism, and IR were analyzed. Results: Compared with the NG group, the levels of NLRP3, ASC, Caspase-1, FBG, HbA₁C, TG, LDL-C, FINs, and HOMA-IR were higher (P β were lower (P P β were seen (P P β. Regression analysis further showed that blood glucose related indexes, FINs, and NLRP3 have made a decisive contribution to IR. Conclusions: Collectively, this evidence suggested that NLRP3 is closely related to glucose and lipid metabolism, and IR, and activated in PDM and T2DM.

关 键 词：Type 2 Diabetes Mellitus Pre-Diabetes Mellitus NLRP3 Glucose and Lipid Metabolism Insulin Resistance 

分 类 号：R58[医药卫生—内分泌]