回医烙灸疗法对佐剂性关节炎大鼠的治疗作用研究  

Therapeutical Effect of Hui Medicine Lao Moxibustion on Adjuvant Arthritis in Rats

作　　者：夏铂[1] 范灵[1] 马英锋[1] 徐武清[1] 

机构地区：[1]宁夏医科大学,银川750004

出　　处：《宁夏医科大学学报》2016年第12期-,共5页Journal of Ningxia Medical University

基　　金：宁夏自然科学基金(NZ14094)

摘　　要：目的研究回医烙灸疗法对佐剂性关节炎大鼠的治疗作用。方法将60只大鼠分为正常组、模型组、甲基强地松龙组和烙灸组,每组15只。其中每组10只做大鼠体重、足跖肿胀度、关节炎指数测量评定,其余5只做足跖骨及膝关节滑膜组织HE染色,观察佐剂关节炎大鼠组织形态的变化。结果 1)模型组、甲基强地松龙组和烙灸组大鼠造模第10、30天体重均低于正常组(P均<0.05)。造模第10天,甲基强地松龙组和烙灸组大鼠体重低于模型组;造模第30天,模型组、甲基强地松龙组和烙灸组体重呈递增趋势(P<0.05)。2)模型组、甲基强地松龙组和烙灸组大鼠造模第10、30天足跖肿胀度均高于正常组(P均<0.05)。造模第30天,模型组、甲基强地松龙组和烙灸足跖肿胀度呈递减趋势(P<0.05)。3)甲基强地松龙组和烙灸组造模后第17、30天佐剂性关节炎指数低于模型组,烙灸组又低于甲基强地松龙组(P<0.05)。4)足跖骨及膝关节滑膜组织HE染色图示,造模后第17天模型组骨、软骨及滑膜组织破坏较严重,甲基强地松龙组、烙灸组破坏程度轻于模型组。结论回医烙灸疗法对佐剂性关节炎大鼠具有治疗作用。Objective To explore on the therapeutical effect of Hui Medicine Lao Moxibustion on adjuvant arthritis in rats.Methods Adjuvant arthritis rat model was employed. 60 rats were divided into normal group, model group,methylprednisolone group,Hui Medical Lao Moxibustion group,each group of 15 rats. Body weight,foot metatarsus swelling degrees,and arthritis index were measured in 10 rats of each group while foot metatarsus and knee joint synovial tissue HE staining were performed in another 5 rats of each group for observing the morphology changes of of adjuvant arthritis rats.Results ①The rats weight of model group, methylprednisolone group and Hui Medicine Lao Moxibustion group were significantly lower than that of the normal group at the 10th and 30th day(P<0.05). At the 10th day,the body weight of the rats in the methylprednisolone group and the Lao Moxibustion group were significantly lower than that in the model group. At the 30th day,the body weight of themodel group,methylprednisolone group and Lao Moxibustion group increased gradually(P<0.05).②The swelling degrees of the model group,methylprednisolone group and moxibustion group were significantly higher than that of the normal group at the 10th and 30th day(P<0.05). At the 30th day,the swelling degree of the model group,the methylprednisolone group and the Lao Moxibustion group decreased gradually(P<0.05). ③The adjuvant arthritis index of the methylprednisolone group and the Lao Moxibustion group were significantly lower than that of the model group at the 17th and the 30th day while the adjuvant arthritis index of the Lao Moxibustion group was significantly lower than that of the methylprednisolone group(P<0.05). ④HE staining of the foot metatarsus and the knee joint synovial tissue showed that the damage of bone,cartilage and synovial tissue in model group was more serious at the 17th day after the model establishment. The degree of damage of methylprednisolone group and Lao Moxibustion group was significantly lighter than that of model group.Concl

关 键 词：回医烙灸 佐剂性关节炎 大鼠 治疗 

分 类 号：R29[医药卫生—民族医学]