181个周期宫腔内夫精人工授精临床结局及其影响因素分析  

Analysis of the results and the influencing factors of intrauterine insemination with husband sperm in 181 cycles

作　　者：王迪[1] 郭丰[1] 王霞[1] 鞠春梅[1] 张美云[1] 郁敏燕[1] 包学云[1] 马晓琳[1] 

机构地区：[1]226001,南通大学附属医院生殖医学中心

出　　处：《中国综合临床》2015年第4期-,共4页Clinical Medicine of China

摘　　要：目的：分析行宫腔内夫精人工授精患者的临床资料，探讨影响夫精人工授精妊娠率的相关因素。方法回顾性分析2013年3月至2014年5月因不孕症在我院进行夫精宫腔内人工授精（IUI）治疗的夫妇98对，共181个周期的临床资料。分析女性的年龄、不孕的年限、是否促排卵及注入宫腔内的前向活动精子数（ TMS）等因素和妊娠之间的关系。结果共有26例妊娠，周期临床妊娠率14.36%。（1）随着年龄增加妊娠率下降，但差异无统计学意义（χ2=1.6549，P =0.647）。（2）不孕年限间临床妊娠率比较差异无统计学意义（χ2=1.5885，P =0.662）。（3）继发性不孕的妊娠率低于原发性不孕的妊娠率，但差异无统计学意义（χ2 =0.9233，P =0.337）。（4）促排卵周期的妊娠率低于自然周期，但差异无统计学意义（χ2=2.2220，P =0.136）。（5）优化后前向活动精子总数≥1000万的患者行 IUI 术后妊娠率与精子数 ＜ 1000万组的患者比较，差异无统计学意义（χ2 =0.6434，P =0.422）。结论在夫精人工授精中，患者的年龄、不孕年限、不孕类型、是否促排卵治疗和优化后前向活动精子总数等均可能影响妊娠率，但差异无统计学意义。治疗时应综合考虑多种因素的影响。Objective To analyze the outcome of patients receiving intrauterine insemination with husband sperm,in order to evaluate the effect of relative factors on pregnancy rate after intrauterine insemination. Methods Ninety-eight infertile couples who received intrauterine insemination in the Affiliated Hospital of Nantong University from March 2013 to May 2014 were selected as our subjects and 181 cycles were included. The information including clinical factors including maternal age,infertile time,infertile causes, ovulation induction protocol,time of insemination and postwash total motitle sperm(TMS)and pregnancy rate were recorded. Results (1)Totally 26 patients received clinical pregnancies,and clinical pregnancy rate(CPR) was 14. 36% per cycle. With age increase pregnancy rate decreased( χ2 = 1. 654 9,P = 0. 647).(2)The pregnancy rate of the patients was the same within the infertile time( χ2 = 1. 588 5,P = 0. 662).(3)The pregnancy rate of the patients with secondary infertility was lower than that of the patients with primary infertility,but there was no significant difference(χ2 = 0. 923 3,P = 0. 337).(4)The pregnancy rate of ovulation induction cycles was lower than that of nature cycles,but there was no significant difference(χ2 = 2. 222 0,P= 0. 136).(5)Postwash TMS was showed the same trend(χ2 = 0. 643 4,P = 0. 422). Conclusion In terms of intrauterine insemination with husband sperm,age,infertile time,infertile types,ovulation induction protocol and posrwash TMS can affect pregnancy rate,and the effects of various factors should be considered comprehensively in the process of therapy.

关 键 词：宫腔内人工授精 妊娠率 影响因素 

分 类 号：R5[医药卫生—内科学]