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医药卫生—病理学: 作品数：45574被引量：140848H指数：63; 导出分析报告; 相关作者：唐朝枢王万铁唐朝克黄岚杜军保更多>>; 相关机构：华中科技大学南华大学中南大学第二军医大学更多>>; 发文主题：病理学细胞凋亡病理生理学炎症小鼠更多>>; 相关期刊：更多>>; 发文基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金国家教育部博士点基金更多>>

Exploring the role of N-acetyltransferases in diseases:a focus on N-acetyltransferase 9 in neurodegeneration: 《Neural Regeneration Research》2025年第10期2862-2871,共10页Prajakta Deshpande Anuradha Venkatakrishnan Chimata Amit Singh; supported by 1RO1EY032959-01 and RO1 supplement from NIH,Schuellein Chair Endowment Fund and STEM Catalyst Grant from the University of Dayton(to AS).; Acetyltransferases,required to transfer an acetyl group on protein are highly conserved proteins that play a crucial role in development and disease.Protein acetylation is a common post-translational modification pivo...; 关键词：acetyl-coenzyme A Alzheimer’s disease animal models cell death DROSOPHILA eye human disease c-Jun N-terminal kinase signaling N-Acetyltransferases N-acetyltransferase 9 NEURODEGENERATION

Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications被引量：1: 《Neural Regeneration Research》2025年第10期2872-2886,共15页Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli Ali Mohamed Margherita Piccolella Mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti; supported by:Fondazione Telethon-Italy(No.GGP19128 to AP);Fondazione Cariplo-Italy(No.2021-1544 to RC);Fondazione Italiana di Ricerca per la Sclerosi Laterale Amiotrofica(AriSLA)-Italy(No.MLOpathy to AP;Target-RAN to AP);Association Française contre les Myopathies-France(AFM Telethon No.23236 to AP);Kennedy’s Disease Association-USA(2018 grant to RC;2020 grant to MG);Ministero dell’Universitàe della Ricerca(MIUR)-Italy(PRIN-Progetti di ricerca di interesse nazionale(No.2017F2A2C5 to AP;No.2022EFLFL8 to AP;No.2020PBS5MJ to VC;No.2022KSJZF5 to VC);PRIN-Progetti di ricerca di interesse nazionale-bando 2022,PNRR finanziato dall’Unione europea-Next Generation EU,componente M4C2,investimento 1.1(No.P2022B5J32 to RC and No.P20225R4Y5 to VC);CN3:RNA-Codice Proposta:CN_00000041;Tematica Sviluppo di terapia genica e farmaci con tecnologia a RNA(Centro Nazionale di Ricerca-CN3 National Center for Gene Therapy and Drugs based on RNA Technology to AP);Progetto Dipartimenti di Eccellenza(to DiSFeB);Ministero della Salute,Agenzia Italiana del Farmaco(AIFA)-Italy(Co_ALS to AP);Universitàdegli Studi di Milano(piano di sviluppo della ricerca(PSR)UNIMI-linea B(to RC and BT).; Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock proteins.HSPB8 is involved in various cellular mechanisms mainly related to prote...; 关键词：AGGREGATION AUTOPHAGY cancer CHAPERONE chaperone-assisted selective autophagy cognitive impairment HSPB8 NEUROINFLAMMATION neuromuscular diseases therapy

Misdiagnosis of psoriatic arthritis in a patient with paronychia confirmed by dermatological examination:A case report: 《World Journal of Clinical Cases》2025年第18期60-64,共5页Angelo Nigro; BACKGROUND This case highlights the importance of a multidisciplinary approach in differentiating localized infections from systemic inflammatory diseases like psoriatic arthritis.Nail psoriasis can mimic conditions l...; 关键词：Psoriatic arthritis PARONYCHIA MISDIAGNOSIS Multidisciplinary approach Case report

社区老年人多维衰弱研究进展: 《中国全科医学》2025年第10期1281-1288,共8页赵琳琳罗琪胡清华陈小垒杜娟邵爽; 北京市高层次公共卫生技术人才建设项目(学术骨干-03-26);北京市教育委员会科研计划项目(SZ202110025009)。; 衰弱已从强调以躯体衰弱为主的单一维度,发展为涵盖躯体衰弱、心理衰弱、社会衰弱等的多维度概念。围绕社区老年人开展多维衰弱的研究是解决目前居家养老服务碎片化难题,提升老年人全面健康的重要途径。本文通过梳理多维衰弱概念的演进...; 关键词：衰弱老年人评估工具社区人群多维衰弱影响因素分析综述

肝硬化门静脉血栓形成机制研究进展: 《协和医学杂志》2025年第2期439-447,共9页武雅荣张永强郑英王彩红; 甘肃省卫生行业科研计划项目(GSWSKY2023-303);兰州市科技计划项目(2023-4-1);联勤保障部队第九四〇医院G计划类项目(2024-G2-4)。; 门静脉血栓(portal vein thrombosis,PVT)是肝硬化最常见的并发症之一,其形成可增高肝硬化患者病死率,影响肝移植的顺利实施和预后。高凝状态是肝硬化患者PVT形成的特殊机制。近年来,PVT的发病机制逐渐明晰,具体机制包括以下几个方面:...; 关键词：肝硬化门静脉血栓炎症反应凝血系统纤溶系统血管内皮细胞肠道菌群

甘肃省60岁及以上老年人慢性病共病现状及影响因素研究: 《中国全科医学》2025年第10期1193-1199,1206,共8页朱先尚曾泓钰吕凤丽王建成; 国家自然科学基金资助项目(72264002);中国医药教育协会重大项目(2022KTZ010);甘肃省人民医院院内科研基金项目(22GSSYD-54)。; 背景随着我国人口老龄化进程的加速,老年慢性病共病现象愈发普遍。这不仅严重影响老年人的生活质量,还给家庭和社会带来沉重负担。甘肃省是西北地区人口老龄化程度较高的省份,亟须关注老年人慢性病共病问题。目的了解甘肃省老年人慢性...; 关键词：慢性病共病老年人患病率共病模式影响因素分析甘肃

血清心型脂肪酸结合蛋白、中性粒细胞明胶酶相关脂质运载蛋白和半乳糖凝集素-3水平与急性心肌梗死患者冠状动脉病变程度的相关性及其对患者预后的预测价值: 《新乡医学院学报》2025年第4期300-303,309,共5页刘朏杜洪洋李晗; 河南省医学科技攻关计划联合共建项目(编号:LHGJ20210776)。; 目的探讨血清心型脂肪酸结合蛋白(H-FABP)、中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、半乳糖凝集素-3(Gal-3)水平与急性心肌梗死(AMI)患者冠状动脉病变程度的相关性及其对患者预后的预测价值。方法选择2022年2月至2023年2月郑州大学附...; 关键词：心型脂肪酸结合蛋白中性粒细胞明胶酶相关脂质运载蛋白半乳糖凝集素-3 急性心肌梗死冠状动脉病变

Gut microbiota-astrocyte axis: new insights into age-related cognitive decline: 《Neural Regeneration Research》2025年第4期990-1008,共19页Lan Zhang Jingge Wei Xilei Liu Dai Li Xiaoqi Pang Fanglian Chen Hailong Cao Ping Lei; supported by the Haihe Laboratory of Cell Ecosystem Innovation Foundation,No.22HHXBSS00047(to PL);Graduate Science and Technology Innovation Project of Tianjin,No.2022BKY173(to LZ);Tianjin Municipal Science and Technology Bureau Foundation,No.20201194(to PL).; With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent worldwide.Aging is considered the main risk factor for cognitive decline and acts through alterati...; 关键词：age aging Alzheimer’s disease ASTROCYTES cognitive decline dementia gut microbiota gut–brain axis microbial metabolites NEUROINFLAMMATION Parkinson’s disease

The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence: 《Neural Regeneration Research》2025年第4期1153-1163,共11页Susana Mellado María JoséMorillo-Bargues Carla Perpiñá-Clérigues Francisco García-García Victoria Moreno-Manzano Consuelo Guerri María Pascual; supported by grants from the Spanish Ministry of Health-PNSD(2019-I039 and 2023-I024)(to MP);FEDER/Ministerio de Ciencia e Innovación-Agencia Estatal de Investigación PID2021-1243590B-I100(to VMM);GVA(CIAICO/2021/203)(to MP);the Primary Addiction Care Research Network(RD21/0009/0005)(to MP);a predoctoral fellowship from the Generalitat Valenciana(ACIF/2021/338)(to CPC).; Our previous studies have reported that activation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with ...; 关键词：ADOLESCENCE binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD- LRR-and pyrin domain-containing protein 3(NLRP3)

老年慢性病患者用药体验对用药依从性的影响研究: 《中国全科医学》2025年第11期1309-1314,共6页高敏李晓娜时永利李子源董平丰志强马东平尹文强陈钟鸣; 国家自然科学基金面上项目(72274140);山东省级人才工程(tsqn202312250);山东省人文社会科学课题(2022-JCGL-02);中国博士后科学基金面上资助项目(2023M740873)。; 背景随着老龄化程度的加剧,老年慢性病患者的规模不断扩大,用药依从性对慢性病患者的健康结局至关重要。现有研究大多分析了用药依从性的影响因素和干预措施对提升用药依从性的效果,但从用药体验角度分析对用药依从性影响的研究还不够...; 关键词：慢性病老年人用药体验用药依从性多元线性回归

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