国家自然科学基金(20272004)

作品数：2被引量：2H指数：1
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相关作者：杨晓鸣邹晓民徐萍傅翌秋牟科更多>>
相关机构：北京大学更多>>
相关期刊：《Journal of Chinese Pharmaceutical Sciences》《Chinese Chemical Letters》更多>>
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Synthesis of Hydroxyethylene-based β-Secretase Inhibitors
《Journal of Chinese Pharmaceutical Sciences》2006年第2期101-108,共8页杨晓鸣 邹晓民 傅翌秋 牟科 徐萍 
National Natural Science Foundation of China(20272004 and 20572006);985 Program, Min-istry of Education of China.
Aim To discuss in depth the synthesis of hydroxyethylene dipeptide-based β-secretase inhibitors; Methods Organic reactions such as nucleophilic addition and substitution assisted by organometallic agents, catalytic h...
关键词：Β-SECRETASE PEPTIDOMIMETICS hydroxyethylene dipeptide isostere SYNTHESIS 
Solid-phase Synthesis of PNA Monomer by Ugi Four-component Condensation Reaction被引量：2
《Chinese Chemical Letters》2005年第5期585-588,共4页WenHaoWANG XiaoMinZOU XinZHANG YiQiuFU PingXU 
This work was supposed by the National Basic Research Program(973 Program)from the Ministry of Science and Technology of China(G1998051114);the National Natural Science Foundation of China(20272004)
Peptide nucleic acids (PNA) oligomers were synthesized in most cases by peptide synthesis from N-protected monomers. In this work a new method of obtaining PNA monomer by Ugi four-component condensation reaction was t...
关键词：Peptide nucleic acids (PNA) Ugi four-component condensation reaction (U-4CR) Solid-phase synthesis Isocyanide. 
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