supported by grants from the National Institutes of Health,USA(R01AG038710,R01AG021173,R01AG044420 and R01NS046673);the Alzheimer’s Association,the National Natural Science Foundation of China(91332112,81225008 and 81161120496);Fundamental Research Funds for the Central Universities of China;the Fok Ying Tung Education Foundation
The degeneration of cholinergic neurons and cholinergic hypofunction are pathologies associated with Alzheimer's disease (AD). Muscarinic acetylcholine receptors (mAChRs) mediate acetylcholine-induced neurotransm...