This work was supported by the following grants:National Natural Science Foundation of China(No.81071164,No.81271584);Zhejiang Provincial Natural Science Foundation of China(No.Y2110782);Public Technology for Applied Research Program Foundation from the Science and Technology Bureau of Zhejiang Province(No.2013C31002);Key Program Foundation from the Health Bureau of Zhejiang Province(No.2013ZDA020);the General Program Foundation from the Hangzhou City Health Bureau(No.2013A27).
Objective:to evaluate the therapeutic effect of targeted endostatin-loaded microbubbles,combined with improved,focused,directional ultrasound radiation for inhibition of subcutaneous translocation in situ colon tumor ...