This work was supported in part by the grants from the National Natural Science Foundation of China (20335020 and 90608006), the Program for Changjiang Scholars and Innovative Research Team in University (No. IRT0445), and the Science and Technology Department of Hunan Province (No. 2006JT2008) We gratefully acknowledge the Department of Pathology, the Second Xiangya Hospital, Central South University (Changsha, China) for their role in obtaining breast cancer tissue samples.
Human epidermal growth factor receptor 2 (HER2) is highly expressed in approximately 30% of breast cancer patients, and substantial evidence supports the relationship between HER2 overexpression and poor overall sur...