supported by the 111 Project(No.111-2-06);National Natural Science Foundation of China(32001064);Key Research and Development Program of China(2021YFC2100102-03);China Postdoctoral Science Foundation(2020M671331);Postgraduate Research and Practice Innovation Program of Jiangsu Province(No.KYCX20-1807).
The purpose of this study was to assess the potential application of cell surface display in Candida tropicalis.Surface display gene cassettes were constructed using five anchoring proteins from Saccharomyces cerevisi...
supported by Foundation of Fujian Key Laboratory of Functional Aquafeed and Culture Environment Control(No.FACE20200003);111 Project(111-2-06)and Jiangsu province“Collaborative Innovation Center for Advanced Industrial Fermentation”industry development program.
The biological treatment of wastewater with high concentrations of ammonia nitrogen has become a hot research issue,but there are limited reports on the mechanism of ammonia nitrogen utilization by microorganisms.In t...
supported by the National Natural Science Foundation of China (Nos. 21472070 and 22177040);partly supported by the 111 Project (No. 111-2-06)。
Staphylococcus aureus wall teichoic acids(WTAs) are attractive targets for antibacterial vaccine development. In this study, three core glycosylated WTA structure, including α-1,4-Glc NAc, β-1,4-Glc NAc andβ-1,3-Gl...
The work was supported by the 111 Project(No.111-2-06);National Natural Science Foundation of China(32001064);Key Research and Development Program of China(2021YFC2100102-03);China Postdoctoral Science Foundation(2020M671331);Postgraduate Research and Practice Innovation Program of Jiangsu Province(No.KYCX20-1807).
The traditional homologous recombination(HR)gene-editing method faces problems such as low editing efficiency and absence of marker genes.CRISPR-Cas9-editing efficiency is high and has been widely used in bacteria and...
supported by the National Natural Science Foundation of China(Nos.21907038 and 32000904);Natural Science Foundation of Jiangsu Province(No.BK20200601);National Postdoctoral Program for Innovative Talents of China(No.BX20200153);China Postdoctoral Science Foundation(Nos.2018M632227 and2021M691293);the Social Development Key Project of Jiangsu Province(No.BE2019632);the Health and Family Planning Commission of Wuxi,China(No.Z202005);Suzhou People’s Livelihood Science and Technology Project,China(No.SYS2018100);supported by the 111 Project(No.111-2-06)。
We construct MUC1 vaccines usingβ-cyclodextrin grafted chitosan(CS-g-CD)as carrier via host-guest interaction.These vaccines based on non-covalent assembling can provoke robust immune responses,including high level o...
supported by the Foundation of Fujian Key Laboratory of Functional Aquafeed and Culture Environment Control(No.FACE20200003);the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions,Top-notch Academic Programs Project of Jiangsu Higher Education Institutions,1.111 Project(111-2-06);Jiangsu province"Collaborative Innovation Center for Advanced Industrial Fermentation"industry development program.
An efficient ammonia nitrogen degrading bacterial strain was isolated from a fish and shrimp pond and identified as Bacillus subtilis(Ab03).Firstly,the strain was continuously domesticated in ammonium solution to impr...
supported by the National Natural Science Foundation of China(Nos.22077052,21877052,21907039 and 22107037);the China Postdoctoral Science Foundation(Nos.2020M681487 and 2021M691279);the National Key R&D Program of China(No.2020YFA0908304);the Natural Science Foundation of Jiangsu Province(Nos.BK20180030 and BK20190575);the National First-class Discipline Program of Light Industry Technology and Engineering(No.LITE2018-14);the 111 Project(No.111-2-06);the Open Project of Key Laboratory of Carbohydrate Chemistry and Biotechnology(Jiangnan University),Ministry of Education(No.KLCCB-KF202005)。
The ribose and phosphorus contents in Haemophilus influenzae type b(Hib)capsular polysaccharide(CPS)are two important chemical indexes for the development and quality control of Hib conjugate vaccine.A quantitative ^(...
This work was supported by the National Natural Science Foundation of China(Nos.22077052,21877052,21907039,22107037);China Postdoctoral Science Foundation(2020M681487,2021M691279);the National Key R&D Program of China(2020YFA0908304);the Natural Science Foundation of Jiangsu Province(BK20180030,BK20190575);the National First-class Discipline Program of Light Industry Technology and Engineering(LITE2018-14);the 111 Project(111-2-06);the Open Project of Key Laboratory of Carbohydrate Chemistry and Biotechnology(Jiangnan University),Ministry of Education(KLCCB-KF202005).
Bacterial surface glycans perform a diverse and important set of biological roles,and have been widely used in the treatment of bacterial infectious diseases.The majority of bacterial surface glycans are decorated wit...
This work received funding from the National Natural Science Foundation of China(No.21878124,22078128,and 21938004);the Fundamental Research Funds for the Central Universities(No.JUSRP221032);the 111 Project(No.111-2-06);the national first-class discipline program of Light Industry Technology and Engineering(LITE2018-24).
Corynebacterium glutamicum represents an emerging recombinant protein expression factory due to its ideal features for protein secretion,but its applicability is harmed by the lack of an autoinduction system with tigh...