V-SRC

作品数:8被引量:2H指数:1
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相关领域:医药卫生生物学更多>>
相关作者:李勃兴谢捷丁晓晓龚兴国钟文涛更多>>
相关机构:浙江大学中国人民解放军第一军医大学浙江中医药大学昆山市第二人民医院更多>>
相关期刊:《中华神经医学杂志》《Acta Pharmacologica Sinica》《北京师范大学学报(自然科学版)》《中国药学杂志》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划国家科技型中小企业技术创新基金上海市自然科学基金更多>>
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Depletion of insulin receptor substrate 2 reverses oncogenic transformation induced by v-src
《Acta Pharmacologica Sinica》2011年第5期611-618,共8页Hong-zhi SUN Lin XU Bo ZHOU Wei-jin ZANG Shu-fang WU 
Acknowledgements We are grateful for the donation of plasmids from Dr Renato BASERGA at the Kimmel Cancer Center. This work was supported by grants from the National Natural Science Foundation of China (Key Program, No 30930105; General Program, No 30971392) and the National Basic Research Program of China (973 Program, No 2007CB512005). This work was also supported by the New Century Excellent Talent in University from the Ministry of Education program (NCET-08-0435) and the "Tengfei" Supporting Program of Xi'an Jiaotong University.
Aim: To investigate the role of insulin receptor substrate 2 (IRS-2) in oncogenic transformation induced by v-src. Methods: IRS-2 gene was silenced using small interfering RNAs (siRNAs). Nuclear translocation an...
关键词:insulin receptor substrate 2 (IRS-2) cellular transformation nuclear translocation V-SRC cyclin D1 promoter rDNA promoter RNA interference 
Expression, purification, and bioactivity of GST-fused v-Src from a bacterial expression system
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2006年第1期13-19,共7页龚兴国 纪静 谢捷 周远 张俊彦 钟文涛 
Project (No. 03C26213300586) supported by the National Innova-tion Fund for Technology, Ministry of Science and Technology of China
v-Src is a non-receptor protein tyrosine kinase involved in many signal transduction pathways and closely related to the activation and development of cancers. We present here the expression, purification, and bioacti...
关键词:V-SRC GST-fusion Inclusion body ORTHOGONALIZATION Protein tyrosine kinase 
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