This work was supported by grants from National Science Technology Major Project"Key New Drug Creation and Manufacturing Program",China(2018ZX09711002 to HZ);the National Natural Science Foundation of China(No.81773757 to MDY;No.81402951 to JC);and Zhejiang Medical and Health Science and Technology Program(No.2020384517 to CYD).
DJ-1 is a multifunctional protein associated with cancers and autosomal early-onset Parkinson disease. Besides the well- documented antioxidative stress activity, recent studies show that DJ-1 has deglycation enzymati...