HOMODIMERIZATION

作品数:5被引量:7H指数:2
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相关领域:生物学更多>>
相关作者:曲宇杰赵阳曹雪松刘国富更多>>
相关机构:聊城大学更多>>
相关期刊:《Acta Pharmacologica Sinica》《Neuroscience Bulletin》《中国生物学文摘》《Cell Research》更多>>
相关基金:国家自然科学基金更多>>
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The C terminus of DJ-1 determines its homodimerization, MGO detoxification activity and suppression of ferroptosis被引量:2
《Acta Pharmacologica Sinica》2021年第7期1150-1159,共10页Li Jiang Xiao-bing Chen Qian Wu Hai-ying Zhu Cheng-yong Du Mei-dan Ying Qiao-jun He Hong Zhu Bo Yang Ji Cao 
This work was supported by grants from National Science Technology Major Project"Key New Drug Creation and Manufacturing Program",China(2018ZX09711002 to HZ);the National Natural Science Foundation of China(No.81773757 to MDY;No.81402951 to JC);and Zhejiang Medical and Health Science and Technology Program(No.2020384517 to CYD).
DJ-1 is a multifunctional protein associated with cancers and autosomal early-onset Parkinson disease. Besides the well- documented antioxidative stress activity, recent studies show that DJ-1 has deglycation enzymati...
关键词:DJ-1 C terminus HOMODIMERIZATION methylglyoxal(MGO)detoxification deglycation ferroptosis HEK293T cells DJ-1−/−mouse embryonic fibroblast cells 
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