SCOLOPENDRA

作品数：9被引量：40H指数：4
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相关领域：医药卫生生物学更多>>
相关作者：陶勇迟程吴刚叶文娟朱绍文更多>>
相关机构：中国科学院中国科学院大学云南中医学院普洱学院更多>>
相关期刊：《Chinese Herbal Medicines》《Chinese Journal of Integrative Medicine》《World Journal of Gastroenterology》《Zoological Research》更多>>
相关基金：国家自然科学基金国家重点实验室开放基金更多>>
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Scorpiones,Scolopendra and Gekko Inhibit Lung Cancer Growth and Metastasis by Ameliorating Hypoxic Tumor Microenvironment via PI3K/AKT/mTOR/HIF-1αSignaling Pathway
《Chinese Journal of Integrative Medicine》2024年第9期799-808,共10页MAO Qi-yuan WANG Xue-qian LIN Fei YU Ming-wei FAN Hui-ting ZHENG Qi LIU Lan-chun ZHANG Chu-chu LI Dao-rui LIN Hong-sheng 
Supported by the Special Scientific Research Project of the Chinese Medicine Industry of the State Administration of Traditional Chinese Medicine of China(No.201307006);National Natural Science Foundation of China(No.82104656,82004179,82074405);Fundamental Research Funds for the Central Public Welfare Research Institutes(No.ZZ14-YQ-013,ZZ15-YQ-024)。
Objective:To investigate whether Buthus martensii karsch(Scorpiones),Scolopendra subspinipes mutilans L.Koch(Scolopendra)and Gekko gecko Linnaeus(Gekko)could ameliorate the hypoxic tumor microenvironment and inhibit l...
关键词：SCORPIONES SCOLOPENDRA Gekko dredging collaterals and activating blood Chinese medicine of worms lung cancer hypoxic tumor microenvironment phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin/hypoxia-inducible factor-1α signaling pathway 
Antihepatoma peptide,scolopentide,derived from the centipede scolopendra subspinipes mutilans被引量：5
《World Journal of Gastroenterology》2023年第12期1875-1898,共24页Yu-Xing Hu Zhuo Liu Zhen Zhang Zhe Deng Zhen Huang Ting Feng Qing-Hong Zhou Si Mei Chun Yi Qing Zhou Pu-Hua Zeng Gang Pei Sha Tian Xue-Fei Tian 
Supported by the National Natural Science Foundation of China,No.U20A20408 and No.82074450;Natural Science Foundation of Hunan Province,No.2020JJ4066 and No.2021JJ40405;Key scientific research project of Hunan Education Department,No.21A0243;Key project of academician workstation guidance project,No.21YSZQ007.
BACKGROUND Centipedes have been used to treat tumors for hundreds of years in China.However,current studies focus on antimicrobial and anticoagulation agents rather than tumors.The molecular identities of antihepatoma...
关键词：SCOLOPENDRA CENTIPEDE Antihepatom peptide Hepatocellular carcinoma Death receptor 4 Death receptor 5 
STAT3 Inhibition by Centipede Scolopendra Extract in Liver Cancer HepG2 Cells and Orthotopic Mouse Models of Hepatocellular Carcinoma被引量：7
《Digital Chinese Medicine》2020年第2期67-79,共13页TENG Yong-Jie LIU Zhuo LIAO Liu CHEN Yuan HUANG Xiao-Di TIAN Xue-Fei 
funding support from the National Natural Science Foundation of China(No.81473617);the Science and Technology Department of Hunan Province(No.2017SK50310);the Hunan Education Department’s Science&Research Project(No.16K066)。
Objective To observe the effects of Centipede Scolopendra extraction(CSE)on human liver cancer HepG2 cells and the nude mouse tumor model of liver orthotopic transplantation,and to explore the anti-liver cancer mechan...
关键词：Centipede Scolopendra extract(CSE) Liver cancer Nude mice Protein tyrosine kinase(PTK) STAT3 Protein chip 
Comparative analysis of diverse toxins from a new pharmaceutical centipede,Scolopendra mojiangica被引量：2
《Zoological Research》2020年第2期138-147,共10页Zi-Chao Liu Jin-Yang Liang Xin-Qiang Lan Tao Li Jia-Rui Zhang Fang Zhao Geng Li Pei-Yi Chen Yun Zhang Wen-Hui Lee Feng Zhao 
supported by grants from the Chinese National Natural Science Foundation(81860696,31560596,81373945,and 31360516);Yunnan Applied Basic Research Projects(2016FD076);Key Research Program of the Chinese Academy of Sciences(KJZD-EW-L03);"Yunling Scholar"Program,Yunnan Provincial Training Programs of Youth Leader in Academic and Technical Reserve Talent(2019HB058);Puer University(2017XJKT12&CXTD011)。
As the oldest venomous animals,centipedes use their venom as a weapon to attack prey and for protection.Centipede venom,which contains many bioactive and pharmacologically active compounds,has been used for centuries ...
关键词：CENTIPEDE TOXINS PHARMACEUTICAL USE Proteotranscriptomic analysis 
Quinoline alkaloids isolated from Scolopendra subspinipes mutilans被引量：2
《Chinese Herbal Medicines》2019年第3期344-346,共3页Yan-fang Li Wu-zhan Liu Jian-wei Fan Chuan-liang Huang Li-hua Deng Hui-fang Zhuang Yong-xia Guan 
supported by the Special Project (No. 1811) for the Scientific & Technological Innovation and Development of Lanshan District, Linyi
Objective: To study the quinoline alkaloids from the ethanol extract of Scolopendra subspinipes mutilans(SSM).Methods: The chemical constituents were isolated and purified by macroporous resin column, medium pressure ...
关键词：3–hydroxy-4-methoxyquinolin-8-yl hydrogen SULFATE jineol jineol-8-sulfate QUINOLINE ALKALOIDS SCOLOPENDRA subspinipes mutilans L. Koch 
Clinical consequences of centipede bite:Is it neurotoxic?
《World Journal of Neurology》2016年第2期23-29,共7页Ioannis N Mavridis Maria Meliou Efstratios-Stylianos Pyrgelis 
The primary purpose of this article was to review the current literature regarding the clinical consequences of centipede envenomation in humans,in order to determine whether the bite of these arthropods is neurotoxic...
关键词：CENTIPEDES Pain Sensory disturbances ENVENOMATION SCOLOPENDRA 
Scolopendra subspinipes mutilans protected the ceruleininduced acute pancreatitis by inhibiting high-mobility group box protein-1被引量：7
《World Journal of Gastroenterology》2013年第10期1551-1562,共12页Il-Joo Jo Gi-Sang Bae Kyoung-Chel Park Sun Bok Choi Won-Seok Jung Su-Young Jung Jung-Hee Cho Mee-Ok Choi Ho-Joon Song Sung-Joo Park 
Supported by National Research Foundation of Korea grant funded by the Korea government MEST,No. 2010-0029498
AIM:To evaluate the inhibitory effects of Scolopendra subspinipes mutilans(SSM) on cerulein-induced acute pancreatitis(AP) in a mouse model.METHODS:SSM water extract(0.1,0.5,or 1 g/kg) was administrated intraperitonea...
关键词：SCOLOPENDRA subspinipes mutilans CYTOKINES Acute PANCREATITIS HIGH-MOBILITY GROUP box protein-1 
中国少棘蜈蚣(Scolopendra subspinipes mutillans)的毒腺结构
《中国细胞生物学学报》2012年第2期162-167,共6页华卫建 徐国华 周祀乔 华子春 
南京大学医药生物技术国家重点实验室开放基金;江苏教育学院科研基金资助项目~~
用免疫组化和光镜、透射电镜等观察了中国少棘蜈蚣毒腺的结构。结果显示,纵贯颚肢的弯月形毒腺为单管泡状腺,主要由柱状分泌细胞和介于其间的纤细表皮细胞组成。被肌肉束环绕的分泌细胞辐射状排列于几丁质的毒液导管外,其纤细的颈部由...
关键词：少棘蜈蚣 毒腺 显微结构 超微结构 免疫组化 分泌溶酶体 
蜈蚣(Scolopendra subspinipes mutilans L.Koch)毒的化学组成和生物活性被引量：18
《生物化学杂志》1992年第2期144-149,共6页吴刚 冉永禄 凌沛深 陶勇 唐向辉 叶文娟 迟程 朱绍文 
系统分析少棘蜈蚣粗毒的化学组成,蛋白质含量86.23％、水不溶物质0.24％、还原糖0.23％、水份2.1％,仅含Ser、Pro、Arg等三种游离氨基酸,鉴定了11种微量元素,碱性凝胶电泳显示20条蛋白质谱带。分析了10种酶的活性、出血毒性及对血小板...
关键词：生物活性 化学组成 蜈蚣毒 
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