This work was partly supported by the National Natural Science Foundation of China(Nos.61773196 and 32070681);2019 Key Projects of Ministry of Science and Technology of China(No.2019YFA09006000);Guangdong Provincial Key Laboratory of Computational Science and Material Design(No.2019B030301001);Shenzhen Research Funds(No.JCYJ20170817104740861);Shenzhen Peacock Plan(No.KQTD2016053117035204);by Center for Computational Science and Engineering of Southern University of Science and Technology.
Background:The lipostatic set-point theory,ascribing fat mass homeostasis to leptin mediated central feedback regulation targeting the body9s fat storage,has caused a variety of conundrums.We recently proposed a leano...