We gratefully acknowledge the financial support from the National Key Research and Development Program of China(2019YFA0906201,2020YFA090032,2022YFC2105400);the National Natural Science Foundation of China(22307037,21907031,81903529,21977029,31720103901,21877124);the Open Project Funding of the State Key Laboratory of Bioreactor Engineering,the 111 Project(B18022).
Fungal bifunctional terpene synthases(BFTSs)catalyze the formation of numerous di-/sester-/tri-terpenes skeletons.However,the mechanism in controlling the cyclization pattern of terpene scaffolds is rarely deciphered ...