LIDAMYCIN

作品数：19被引量：65H指数：6
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相关领域：医药卫生更多>>
相关作者：刘芳陈淑珍商悦甄永苏吴淑英更多>>
相关机构：中国医学科学院北京协和医学院中国医学科学院中国协和医科大学清华大学更多>>
相关期刊：《Science Bulletin》《中国抗生素杂志》《Science China(Life Sciences)》《Acta Pharmacologica Sinica》更多>>
相关基金：国家高技术研究发展计划国家自然科学基金国家重点基础研究发展计划更多>>
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Optimization of the Assembly Efficiency for Lidamycin Chromophore Bound to its Apoprotein:A Case Study using Orthogonal Array被引量：9
《Biomedical and Environmental Sciences》2011年第6期602-607,共6页ZHONG Gen Shen GUO Xiao Fang ZHANG Sheng Hua ZHEN Yong Su 
supported by grants from "Significant new drug development" Science and Technology Major Projects of China (2009ZX09301-003; 2009ZX09401-005; 2010ZX09401-407)
Objective Lidamycin （LDM） can be dissociated to an apoprotein （LDP） and an active enediyne chromophore （AE）. The detached AE can reassemble with its LDP-containing fusion protein to endow the latter with potent ...
关键词：LIDAMYCIN CHROMOPHORE HPLC Orthogonal array Assembly rate Lidamycin CHROMOPHORE HPLC Orthogonal array Assembly rate 
Role of Prosurvival Molecules in the Action of Lidamycin toward Human Tumor Cells
《Biomedical and Environmental Sciences》2009年第3期244-252,共9页A-JING YANG WEI-WEI SHI YONG LI ZHEN WANG RONG-GUANG SHAO DIAN-DONG LI QI-YANG HE 
supported by grants from the National Natural Science Foundation of China (No. 30672482);the National 973 Program (No. 2009CB521807)
Objective Lidamycin, an enediyne antibiotic, leads to apoptosis and mitotic cell death of human tumor cells at high and low concentrations. The reason why tumor cells have distinct responses to lidamycin remains elusi...
关键词：LIDAMYCIN Prosurvival molecules SIRTI deacetylase Apoptosis Mitotic cell death Multidrug resistance 
Effect of Lidamycin on Telomerase Activity in Human Hepatoma BEL-7402 Cells被引量：3
《Biomedical and Environmental Sciences》2007年第3期189-197,共9页RUI-JUAN GAO YUE-XIN LIANG DIAN-DONG LI HONG-YIN ZHANG YONG-SU ZHEN 
This study was supported by the National High Technology Research and Development Program of China (863 Programm Grant No.2006AA02A255);the National Natural Science Foundation of China (Grant No.30472042; 30300424).
Objective To investigate the effect of lidamycin （LDM） on telomerase activity in human hepatoma BEL-7402 cells under the condition of LDM inducing mitotic cell death and senescence. Methods Chromatin condensation wa...
关键词：LDM Mitotic cell death Cellular senescence Telomerase activity 
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