AZOLE

作品数：47被引量：35H指数：3
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  • 期刊=Chinese Chemical Lettersx
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Conventional and microwave irradiated synthesis,biological activity evaluation and molecular docking studies of highly substituted piperazine-azole hybrids
《Chinese Chemical Letters》2017年第5期995-1005,共11页Arif Mermer Serpil Demirci Serap Basoglu Ozdemir Ahmet Demirbas Serdar Ulker Faik Ahmet Ayaz Fatma Aksakal Neslihan Demirbas 
provided by Scientific and Technological Research Council of Turkey(TUBITAK,No.113Z181)
Azole derivatives（3,6） obtained starting from 1-（2-methoxyphenyl） piperazine were converted to the corresponding Mannich bases containing β-lactame or flouroquinolone core via a one pot three component reaction.T...
关键词：Fluoroquinolone 1 2 4-Triazole Microwave Mannich reaction Biological activity Molecular docking 
Design,synthesis and biological evaluation of novel non-azole derivatives as potential antifungal agents被引量：1
《Chinese Chemical Letters》2015年第9期1161-1164,共4页Hui Tang Juan Wu Wen Zhang Lei Zhao Ya-Hui Zhang Cheng-Wu Shen 
supported by the Shandong Natural Science Foundation(No.ZR2012HQ026);the Foundation of Sichuan Provincial Health Department(No.110480)
A series of 3-substituted quinazolinones,2-substituted quinoxalines and 2-substituted benzopyrans were synthesized and evaluated for their antifungal activity in vitro.The new compounds revealed excellent in vitro ant...
关键词：Non-azole Biological evaluation Structure-activity relationships Synthesis Antifungal agents 
A novel carbazole-based fluorescent probe:3,6-B is-[(N- ethylcarb azole- 3-yl)-propene- 1-keto]-N-ethylc arb azole
《Chinese Chemical Letters》2010年第1期9-12,共4页Hao, Li Ling Li, Jun Fen Lin, Pei Hua Dong, Rui Feng Li, Du Xin Shuang, Shao Min Dong, Chuan 
supported by the National Science Foundation of China(No.20875059);the Youth Science Foundation of Shanxi Province(No.20051005).
A novel carbazole-based compound 5,3,6-bis[(N-ethylcarbazole-3-yl)-propene-1-keto]-N-ethylcarbazole has been designed, synthesized and characterized.The absorption and fluorescence spectra in solvents of different pol...
关键词：CARBAZOLE Fluorescent probe Intramolecular charge transfer Synthesis 
Design, Synthesis and Biological Evaluation of Non-azole Inhibitors of Lanosterol 14α-Demethylase of Fungi被引量：1
《Chinese Chemical Letters》2006年第9期1189-1192,共4页Bin YAO You Jun ZHOU Jü ZHU Jia Guo Lü Yao Wu LI Jun CHENG Qing Feng JIANG Can Hui ZHENG 
supported by the National Natural Science Foundation of China(No.30572257)
Novel tetralin compounds were designed and synthesized on the three-dimensional model of lanosterol 14α-demethylase of Candida albicans. All of the lead compounds exhibited potent antifungal activities, especially co...
关键词：ANTIFUNGAL 2-aminotetralins lanosterol 14α-demethylase inhibitor. 
Synthesis of a Photolabeling Probe for the Study of Antiviral Mechanism of Ribavirin被引量：1
《Chinese Chemical Letters》2004年第8期907-910,共4页QiongYouwu XunZHU JinQiaoWAN FanQiQU LingPENG 
Ribavirin has been used in urgency to treat SARS patients recently. In order to study its antiviral mechanism by photolabeling approach, we have synthesized and characterized 5-azido-1-β-D-ribofuranosyl-1,2,4-triazol...
关键词：RIBAVIRIN photolabeling probe of ribavirin azidotriazole nucleoside azole nucleosides photolabeling. 
N-ARYLATION OF AZOLE COMPOUNDS
《Chinese Chemical Letters》1995年第2期95-98,共4页Zhi Sheng JIA Di Lun YANG You Cheng LIU(Deportment of Chemistry, The National Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou 730000) 
The azole anions behave as nucleophiles towards nitro-substituted halobenzene, indicating a classical SNAr mechanism, and the nucleophilicity of azole anions is consistent with the pKa values.
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