supported by the Western Light Project of the Chinese Academy of Sciences and the Young Qihuang Scholars Project of the National Administration of Traditional Chinese Medicine.This research was also funded by the open foundation of Shaanxi University of Chinese Medicine state key laboratory of R&D of Characteristic Qin Medicine Resources(SUCM-QM202202,China);the fund of Traditional Chinese Medicine Institute of Anhui Dabie Mountain(TCMADM-2023-18,China);“Double FirstClass”University Project of China Pharmaceutical University(CPU2022QZ27,China);supported by the key project at the central government level:the ability establishment of sustainable use for valuable Chinese medicine resources(2060302,China);the open research fund of Yunnan characteristic plant extraction laboratory(YKKF2023002,China)。
Coumarins,derived from the phenylpropanoid pathway,represent one of the primary metabolites found in angiosperms.The alignment of the tetrahydropyran(THP)and tetrahydrofuran(THF)rings with the lactone structure result...
National Key Research and Development Program of China (2018YFA0902000);the key project at central government level:the ability establishment of sustainable use for valuable Chinese medicine resources(2060302,China);the open foundation of Shaanxi University of Chinese Medicine state key laboratory of R&D of Characteristic Qin Medicine Resources (SUCM-QM202202,China);the fund of Traditional Chinese Medicine Institute of Anhui Dabie Mountain (TCMADM-2023-18,China);National Natural Science Foundation of China (32070364);Hainan Provincial Natural Science Foundation of China(2019RC309)
Pyran-and furanocoumarins are key representatives of tetrahydropyrans and tetrahydrofurans,respectively,exhibiting diverse physiological and medical bioactivities.However,the biosynthetic mechanisms for their core str...