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Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia被引量：9
《Cell Research》2018年第2期172-186,共15页Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang 
Acknowledgments We thank all the faculties and staffs in the Clinical and Laboratory Unit of the Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology for their clinical and technical support; the Core Genomic Facility of Beijing Institute of Genomics, Chinese Academy of Sciences for the construction and sequencing of libraries; Drs Qing Li and Jiguang Wang for critical reading and valuable comments on the manuscript; Dr Kai Fu for providing the cell line YT. This study was supported by the National Natural Science Foundation of China （81570196 to JZ, 81425003 to QW, 81670152 to Liang H, 81600120 to NW, 81300410 to DW, 81500100 to YL and 81400122 to KZ）, the National Key Basic Research Program of China （2014CB542001 to QW）, the Key Program of the National Natural Science Foundation of China （81230052 to JZ）, the Key Research Program of the Chinese Academy of Sciences （Precious Medicine Research in Chinese Population; KJZD-EW-L14-3 to QW）, and the National High Technology Research and Development Program of China （863 program; 2012AA02A507 to JZ and 2014AA020532 to Liang H）.
Aggressive NK-cell leukemia （ANKL） is a rare form of NK cell neoplasm that is more prevalent among people from Asia and Central and South America. Patients usually die within days to months, even after receiving pro...
关键词：aggressive NK-cell leukemia genomic landscape IL-10 JAK/STAT pathway MYC activation nucleotide syn-thesis glycolysis 
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