In eukaryotes, the 5′,5′-triphosphate-linked 7-meth- ylguanosine (mTG) cap is essential for modulation of mRNA metabolism and protects the mRNA from degradation [1]. Removal of the cap from the 5′-terminus of the...
We thank the beamline scientists at ID14-4 and ID23-1 (ESRF, France), PXI (SLS, Switzerland), BL13B1 (NSRRC, Taiwan) and BL17U (SSRF, Shanghai, China) for assistance and access to syn- chrotron radiation facilities. This work was financially supported by the Agency for Science, Technology and Research in Singapore (HS) and partly by the National Natural Science Foundation of China (31270816) and Zhejiang Provincial Natural Science Fu- oundation of China (LZ 12C05001).
The evolutionarily conserved Lsml-7-Patl complex is the most critical activator of mRNA decapping in eukaryotic cells and plays many roles in normal decay, AU-rich element-mediated decay, and miRNA silencing, yet how ...