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Prioritizing natural-selection signals from the deep-sequencing genomic data suggests multi-variant adaptation in Tibetan highlanders被引量：11
《National Science Review》2019年第6期1201-1222,共22页Lian Deng Chao Zhang Kai Yuan Yang Gao Yuwen Pan Xueling Ge Yaoxi He Yuan Yuan Yan Lu Xiaoxi Zhang Hao Chen Haiyi Lou Xiaoji Wang Dongsheng Lu Jiaojiao Liu Lei Tian Qidi Feng Asifullah Khan Yajun Yang Zi-Bing Jin Jian Yang Fan Lu Jia Qu Longli Kang Bing Su Shuhua Xu 
supported by the Strategic Priority Research Program(XDB13040100 to S.X.);Key Research Program of Frontier Sciences(QYZDJ-SSW-SYS009 to S.X.)of the Chinese Academy of Sciences(CAS);the National Natural Science Foundation of China(NSFC)(91731303,31525014,31961130380 and 31771388 to S.X.;31501011 to Y.L.;31771389 to Y.Y.(Yuan Yuan);81522014 to Z.J.;31871256and 31601046 to H.L.;31460286,31660307 and 31260252to L.K.);the Program of Shanghai Academic Research Leader(16XD1404700 to S.X.);the UK Royal Society-Newton Advanced Fellowship(NAF\R1\191094 to S.X.);the National Key Research and Development Program(2016YFC0906403 to S.X.;2017YFA0105300 to Z.J.;2016YFF0202301 to Y.Y.(Yajun Yang));Shanghai Municipal Science and Technology Major Project(2017SHZDZX01 to S.X.);Science and Technology Commission of Shanghai Municipality(STCSM,19YF1455200to L.D.; 16YF1413900 to H.L.);NSFC Research Fund for International Young Scientists(31850410477 to A.K.);CAS President’s International Fellowship for Postdoctoral Researchers(2016 PB036 to A.K.);S.X.is Max-Planck Independent Research Group Leader and member of CAS Youth Innovation Promotion Association;supported by the National Program for Top-notch Young Innovative Talents of the ‘Wanren Jihua’ Project;the UK Royal Society-Newton Mobility Grants(IE160943 to S.X.)
Human genetic adaptation to high altitudes(>2500 m)has been extensively studied over the last few years,but few functional adaptive genetic variants have been identified,largely owing to the lack of deep-genome sequen...
关键词：Tibetan adaptive genetic variant high-altitude adaptation next-generation sequencing(NGS) archaic ancestry expression quantitative traits loci(eQTL) tissue-specific expression hemoglobin concentration hypoxia 
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