ERBB2

作品数：182被引量：334H指数：9
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相关机构：中国科学技术大学第二军医大学军事医学科学院大连医科大学更多>>
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Mechanisms of neratinib resistance in HER2-mutant metastatic breast cancer
《Cancer Drug Resistance》2022年第4期873-881,共9页Lisa D.Eli Shyam M.Kavuri 
Human epidermal growth factor receptor 2 (HER2) is a major drug target and clinical biomarker in breast cancertreatment. Targeting HER2 gene amplification is one of the greatest successes in oncology, resulting in the...
关键词：Neratinib HER2 ERBB2 estrogen receptor MUTATION 
Emerging actionable targets to treat therapyresistant colorectal cancers被引量：2
《Cancer Drug Resistance》2022年第1期36-63,共28页Emanuela Grassilli Maria Grazia Cerrito 
In the last two decades major improvements have been reached in the early diagnosis of colorectal cancer(CRC)and,besides chemotherapy,an ampler choice of therapeutic approaches is now available,including targeted and ...
关键词：Colorectal cancer resistance chemotherapy target therapy EGFR ERBB2 MET BRAF kinase inhibitors immune checkpoint inhibitors gut microbiota 
Targeted lapatinib anti-HER2/ErbB2 therapy resistance in breast cancer:opportunities to overcome a difficult problem被引量：3
《Cancer Drug Resistance》2020年第2期179-198,共20页Reema Wahdan-Alaswad Bolin Liu Ann D.Thor 
Grant support provided in part by Susan G Komen for the Cure K100575 to RSW,SME,and ADT;ACS-IRG 16-184-56 RSW from the American Cancer Society;CCL-C92110 RSW and ADT from the Colorado Cancer League.
Approximately 20%of invasive breast cancers have upregulation/gene amplification of the oncogene human epidermal growth factor receptor-2(HER2/ErbB2).Of these,some also express steroid receptors(the so-called Luminal ...
关键词：HER2/ErbB2 receptor tyrosine kinase tyrosine kinase resistance nuclear receptor androgen receptor lipid metabolism programmed cell death-1 ligand CDK 4/6 inhibitor 
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