BACKGROUND Gastric cancer(GC)is the fifth most common malignancy and the third leading cause of death worldwide.Despite advancements in immunotherapies,patient prognosis remains poor,necessitating the identification o...
National Natural Science Foundation of China,No.82060161,81960154,and 81760156;Jiangxi Provincial Youth Science Foundation,No.2018ACB21040;Natural Science Foundation of Jiangxi Province,No.20212BAB206020;and Foundation of Health commission of Jiangxi Province,No.SKJP220225830.
BACKGROUND The small intestine is known to play a crucial role in the development and remission of diabetes mellitus(DM).However,the exact mechanism by which mid-small intestinal bypass improves glucose metabolism in ...
BACKGROUND Sodium glucose cotransporter-2 inhibitors(SGLT2-I)are the most recently approved drugs for type 2 diabetes(T2D).Recent clinical trials of these compounds reported beneficial cardiovascular(CV)and renal outc...
Supported by the Royal Perth Hospital Medical Research Foundation,No.VMMRF2018。
BACKGROUND Type 1 diabetes(T1D) is associated with major chronic microvascular complications which contribute significantly to diabetes associated morbidity.The protein primarily responsible for glucose reabsorption i...
Liver cirrhosis and diabetes mellitus(DM)are both common conditions with significant socioeconomic burden and impact on morbidity and mortality.A bidirectional relationship exists between DM and liver cirrhosis regard...
Pancreatic cystic lesions(PCLs) have been increasingly recognized in clinical practice. Although inflammatory cysts(pseudocysts) are the most common PCLs detected by cross-sectional imaging modalities in symptomatic p...
supported by the National Natural Science Foundation of China,No.81371591
AIM To investigate the relationship between glucose metabolism and glypican-3(GPc3)expression in hepatocellular carcinoma(Hcc).METHODSImmunohistochemical staining of pathological samples for GPc3 and glucose transport...
Supported by National Natural Science Foundation of China,No.81300329 and No.81401992
AIM To investigate the role of embryonic liver fordin(ELF) in liver fibrosis by regulating hepatic stellate cells(HSCs) glucose glycolysis.METHODS The expression of ELF and the glucose glycolysisrelated proteins were ...
Supported by National Natural Science Foundation of China,No.81000867,No.81272299,No.81301784 and No.81301920;Natural Science Foundation of Jiangsu Province,No.BK20150004 and No.BK20151108;the Fundamental Research Funds for the Central Universities,No.NOJUSRP51619B;Medical Key Professionals Program of Jiangsu Province,No.RC2011031;"333" Talents Project of Jiangsu Province;Hospital Management Center of Wuxi,No.YGZXM1524
AIM: To investigate the role of activating transcription factor 4(ATF4) in glucose deprivation(GD) induced colorectal cancer(CRC) drug resistance and the mechanism involved.METHODS: Chemosensitivity and apoptosis were...
Supported by The China Scholarship Council;No.[2014]3012
Glucose metabolism in gastric cancer cells differs from that of normal epithelial cells. Upregulated aerobic glycolysis(Warburg effect) in gastric cancer meeting the demands of cell proliferation is associated with ge...