supported by the National Institutes of Health(R01CA177585,U01CA240346,and R01CA153821)(DY);the Purdue Center for Cancer Research(P30CA023168);the National Natural Science Foundation of China(82173707 and 82322065);the Program for Jiangsu Province Innovative Research Scholar(JSSCRC2021512);the“Double First-Class”University Project(CPUQNJC22_08).
DNA guanine(G)-quadruplexes(G4s)are unique secondary structures formed by two or more stacked Gtetrads in G-rich DNA sequences.These structures have been found to play a crucial role in highly transcribed genes,especi...