This work was supported the grants from a Program of the Conba-Zhejiang Sci-Tech University, Academician Workstation (No. 116129A4J14365), the National Natural Science Foundation of China (Nos. 81372453 and 81572999), Shanghai Institutes for Biological Science, Chinese Academy of Sciences, and Sichuan Huiyang Life Science and Technology Corp. Research Program (No. Y363S21763).
Lung cancer has a high morbidity rate worldwide and is often resistant to therapy. Oncolytic virus therapy is a developing trend for cancer treatment. Thus, we constructed an oncolytic poxvirus carrying human trail ge...