supported by the National Natural Science Foundation of China(82201011,82030031,92149301 and 82270945);the Beijing Municipal Government grant(Beijing Laboratory of Oral Health,PXM2021-014226-000041);the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2019-I2M-5-038);the Science and Technology Project of Guangzhou,China(202206080009);the Postdoctoral Foundation of China(2021M703695 and 2021TQ0308)。
The gingiva is a key oral barrier that protects oral tissues from various stimuli.A loss of gingival tissue homeostasis causes periodontitis,one of the most prevalent inflammatory diseases in humans.The human gingiva ...