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EPITOPES: 作品数：96被引量：141H指数：7; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：郭礼和费俭夏国宏邢力叶欣更多>>; 相关机构：中国科学院上海生命科学研究院郑州大学南昌大学广州血液中心更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金World Health Organization国家重点基础研究发展计划中国博士后科学基金更多>>

Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1: 《hLife》2024年第10期527-541,共15页Qi Pan Xiaomin Xing Jianhai Yu Qiang Chen Haizhan Jiao Wanqin Zhang Yingfen Wen Ming Gao Wei Zhao Lei Yu Hongli Hu; supported by grants from the National Natural Science Foundation of China(81971924 to L.Y.and 32370146 to W.Z.);Guangzhou Municipal Science and Technology Bureau(2023A03J0791 to L.Y.);Guangdong Science and Technology Program(2021B1212030014 to W.Z.);Guangdong Basic and Applied Basic Research Fund Enterprise Joint Fund(2021A1515220017 to W.Z.);Medical Scientific Research Foundation of Guangdong Province(B2022112 to J.Y.),Shenzhen Science and Technology Innovation Committee(JCYJ20210324131802008 to H.H.);Ganghong Young Scholar Development Fund(to H.H.);the Shenzhen-Hong Kong Cooperation Zone for Technology and Innovation(HZQB-KCZYB-2020056 to H.H.);the Kobilka Institute of Innovative Drug Discovery and Presidential Fellowship and University Development Fund at the Chinese University of Hong Kong,Shenzhen(to H.H.,H.J.,and Q.C.);Presidential Fellowship at the Chinese University of Hong Kong,Shenzhen(to Q.P.and W.Z.)。; Antibodies targeting non-structural protein 1(NS1)confer protection against Zika virus(ZIKV).Although monoclonal an-tibodies(MAbs)3G2 and 4B8 are more potent than MAb 4F10 in suppressing ZIKV infection in neonatal mic...; 关键词：Zika virus(ZIKV) non-structural protein 1(NS1) monoclonal antibodies(MAbs) EPITOPES

SARS-CoV-2 peptides/epitopes for specific and sensitive diagnosis: 《Cellular & Molecular Immunology》2023年第5期540-542,共3页He-Wei Jiang Yang Li Sheng-Ce Tao; the National Key Research and Development Program of China Grant(No.2020YFE0202200);the National Natural Science Foundation of China(Nos.31900112 and 31970130).; The COVID-19 pandemic,caused by SARS-CoV-2,has presented an unprecedented challenge to global public health.The rapid,reliable,and affordable diagnosis of COVID-19 is essential for controlling the spread of the acute ...; 关键词：DIAGNOSIS app false

Peptides-based vaccine against SARS-nCoV-2 antigenic fragmented synthetic epitopes recognized by T cell and β-cell initiation of specific antibodies tofightthe infection: 《Bio-Design and Manufacturing》2021年第3期490-505,共16页Zainularifeen Abduljaleel Faisal A.Al-Allaf Syed A.Aziz; The World Health Organization has declared the rapidly spreading coronavirus to be a global pandemic.The FDA is yet to approve a vaccine for human novel coronavirus.Here,we developed a peptide-based vaccine and used h...; 关键词：COVID-19 SARS-nCoV-2 Peptide-based vaccine Cell-penetrating peptides Lipid membrane Vaccine efficacy

Flu Universal Vaccines: New Tricks on an Old Virus被引量：1: 《Virologica Sinica》2021年第1期13-24,共12页Ruikun Du Qinghua Cui Lijun Rong; supported by The Drug Innovation Major Project(Grant No.2018ZX09711001);the Key Research and Development Projects of Science and Technology Department of Shandong Province(Grant No.2017CXGC1309);Shandong Provincial Natural Science Foundation of China(Grant No.ZR2019MH078,ZR2017MH086); Conventional influenza vaccines are based on predicting the circulating viruses year by year,conferring limited effectiveness since the antigenicity of vaccine strains does not always match the circulating viruses.Thi...; 关键词：Influenza virus Universal vaccine Conserved epitopes Broadly protection

Human Monoclonal Antibodies: On the Menu of Targeted Therapeutics Against COVID-19被引量：1: 《Virologica Sinica》2020年第6期713-724,共12页Junsen Chen Rui Huang Yiwen Nie Xinyue Wen Ying Wu; supported by Grants from the National Science and Technology Major Project (Grant No.2018ZX10733403)。; Coronavirus disease 2019(COVID-19), reminiscent of the severe acute respiratory syndrome(SARS) outbreak in 2003,has been a tragic disaster to people all over the world. As there is no specific drug for COVID-19, neutr...; 关键词：COVID-19 MABS S glycoprotein EPITOPES

Novel antibody epitopes dominate the antigenicity of spike glycoprotein in SARS-CoV-2 compared to SARS-CoV被引量：5: 《Cellular & Molecular Immunology》2020年第5期536-538,共3页Ming Zheng Lun Song; by the National Natural Science Foundation of China(numbers 31570758,91743115,and 31270797)to L.S.; Recently,the World Health Organization(WHO)has declared the novel coronavirus(2019-nCoV)outbreak a Public Health Emergency of International Concern(PHEIC),1 which is now formally named as severe acute respiratory synd...; 关键词：RESPIRATORY acute cases

Epitopes for a 2019-nCoV vaccine: 《Cellular & Molecular Immunology》2020年第5期539-540,共2页Guglielmo Lucchese; by a“Gerhard Domagk”research grant awarded by the University of Greifswald Medical School。; After causing an initial cluster of Pneumonia in Wuhan City,Hubei Province,the 2019-nCoV has quickly spread through South East Asia and within a few weeks to Europe,Africa,and America.Initial estimates suggested a mor...; 关键词：STATEMENT ESTIMATES COMMITTEE

Prediction of promiscuous T-cell epitopes in the Zika virus polyprotein:An in silico approach: 《Asian Pacific Journal of Tropical Medicine》2016年第9期822-828,共7页Hamza Dar Tahreem Zaheer Muhammad Talha Rehman Amjad Ali Aneela Javed Gohar Ayub Khan Mustafeez Mujtaba Babar Yasir Waheed; Objective:To predict immunogenic promiscuous T-cell epitopes from the polyprotein of the Zika virus using a range of bioinformatics tools.To date,no epitope data are available for the Zika virus in the IEDB database.M...; 关键词：Zika VIRUS B-CELL EPITOPES T-CELL EPITOPES Vaccine ANTIGENICITY

Important immunohistochemical markers for identifying sweat glands被引量：1: 《Chinese Medical Journal》2013年第7期1370-1377,共8页LEI Yong-hong LI Xue ZHANG Jin-qian ZHAO Jing-yu; This review was supported by the General Program of National Natural Science Foundation of China （Nos. 30870991 and 30672176）, the Key Program of National Natural Science Foundation of China （No. 30230370）, and the Major State National Basic Science and Development Program （No. 2005CB522603）.; he major adnexal structures of the skin, the sweat glands, regulate the body temperature. There are twotypes of sweat glands in the human body, the eccrine type, which produces the NaCl-rich solution in response to he...; 关键词：sweat glands immunohistochemical marker anttgentc epitopes

Natural epitope variants of the hepatitis C virus impair cytotoxic T lymphocyte activity被引量：1: 《World Journal of Gastroenterology》2010年第16期1953-1969,共17页Shuping Wang Rico Buchli Jennifer Schiller Jianen Gao Rodney S VanGundy William H Hildebrand David D Eckels; Supported by The National Institutes of Health, No. NIH-DK-57732; AIM:To understand how interactions between hepatitis C virus(HCV) and the host's immune system might lead to viral persistence or effective elimination of HCV.METHODS:Nucleotides 3519-3935 of the non-structural 3(NS3)...; 关键词：EPITOPES Human T Cells CYTOTOXIC ANERGY VIRAL

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