supported by the National Basic Research Program of China (Grant Nos. 2012CB722301 and 2011CB111605);the National High Technology Research and Development Project of China (Grant No. 2011AA10A203);the National Natural Science Foundation of China (Grant No. 31070006)
To promote spinosad biosynthesis by improving the limited oxygen supply during high-density fermentation of Saccharopolyspora spinosa, the open reading frame of the Vitreoscilla hemoglobin gene was placed under the co...