We thank Dr. Torsten Juelich for linguistic assistance during the preparation of this manuscript. This work was supported by the Ministry of Science and Technology (China) (2015CB910104 to XCZ) and National Natural Science Foundation of China (31470745 to XCZ),
Prokaryotic AcrB-like proteins belong to a family of transporters of the RND superfamily, and as main contributing factor to multidrug resistance pose a tremendous threat to future human health. A unique feature of Ac...