supported by the National Natural Science Foundation of China (10721403);National Basic Research Program of China (2009C-B918500);the National High-Technology Research & Development Program of China (2006AA020400)
The viral infectivity factor (Vif) was found to be essential for controlling HIV-1 virus infectivity. It targets cellular antiviral proteins in APOBEC family (APO) to trigger its fast degradation and inhibits APO pack...