supported by the National Key Research and Development Program(2019YFA0705701);the National Natural Science Foundation of China(22179149,22075329,22008267,51573215 and 21978332);the Basic and Applied Basic Research Foundation of Guangdong province(2021A0505030022,2019A1515010803 and 2020A1515011445);Guangzhou Scientific and Technological Planning Project(201804020025 and 201904010271)。