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Homology modeling three-dimensional structure of AnxB1 and reducing its immunogenicity by sequence-deleted mutagenesis被引量:2
《Science China(Life Sciences)》2004年第4期359-367,共9页YAN Hongli1, SONG Yunlong2, LIU Fan1, HE Yan1 & SUN Shuhan1 1. Department of Medical Genetics, Second Military Medical University, Shanghai 200433, China 2. Department of Medicinal Chemistry, Second Military Medical University, Shanghai 200433, China 
This work was supported by the National High Technology Research;Development Program of China(863 Program)(Grant No.101-060504);the National Natural Science Foundation of China(Grant No.30271167).
AnxB1, a novel annexin previously isolated from Cysticercus cellulose, shows high thrombi affinity and anticoagulant activity in vivo. In order to investigate the relationship between structure and biological function...
关键词:annexin homology modeling sequence-deleted mutant anticoagulant immunogenicity. 
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