PROTEIN-DNA

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Crystal structure of Cas1 in complex with branched DNA被引量：2
《Science China(Life Sciences)》2020年第4期516-528,共13页Jing Yang Jiazhi Li Jiuyu Wang Gang Sheng Min Wang Hongtu Zhao Yanhua Yang Yanli Wang 
The research was funded by the National Natural Science Foundation of China(31630015,31725008);the Chinese Academy of Sciences(QYZDY-SSW-SMC021).
Cas1 is a key component of the CRISPR adaptation complex,which captures and integrates foreign DNA into the CRISPR array,resulting in the generation of new spacers.We have determined crystal structures of Thermus ther...
关键词：CRISPR CAS protein Cas1 ADAPTATION DNA integration structure PROTEIN-DNA COMPLEX 
Evolutionary conservation and DNA binding properties of the Ssh7 proteins from Sulfolobus shibatae
《Science China(Life Sciences)》2002年第6期583-592,共10页陈绪林 郭荣 黄力 Ray Hong 
This work was supported by the National Natural Science Foundation of China (Grant Nos. 39770006 & 39925001)
The thermoacidophilic archaeon Sulfolobus shibatae synthesizes a large amount of the 7-ku DMA binding proteins known as Ssh7. Our hybridization experiments showed that two Ssh7-encoding genes existed in the genome of ...
关键词：HYPERTHERMOPHILIC archaea  DNA BINDING proteins  ssh7a/ssh7b genes  PROTEIN-DNA interaction. 
Effect of DNA methylation on protein-DNA interaction of HL-60 cells
《Science China(Life Sciences)》1999年第5期501-505,共5页何忠效 白坚石 张昱 
HL-60 cells have been induced with differentiation index 16% by S-adenosyl-L-methionine (SAM) as in-ducer in the presence of optimum concentration of 10 μmol/L. The methylation level of genome DNA determined by HPLC ...
关键词：S-ADENOSYL-L-METHIONINE (SAM) HL-60 cell DNA METHYLATION PROTEIN-DNA interaction. 
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