云南高校图书馆联盟文献共享服务平台- PYRIN

PYRIN: 作品数：168被引量：463H指数：10; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：韩蓉吴东明许颖郭兵肖瑛更多>>; 相关机构：贵州医科大学空军军医大学南方医科大学成都医学院第一附属医院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金新疆维吾尔自治区自然科学基金陕西省自然科学基金山东省医药卫生科技发展计划项目更多>>

Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss: 《Neural Regeneration Research》2025年第5期1483-1494,共12页Xihang Chen Zhifeng Chen Menghua Li Weiwei Guo Shuolong Yuan Liangwei Xu Chang Lin Xi Shi Wei Chen Shiming Yang; supported by the National Key Research and Development Program of China,No.2022YFC2402701(to WC);Key International(Regional)Joint Research Program of the National Natural Science Foundation of China,No.81820108009(to SY);the National Natural Science Foundation of China,Nos.81970890(to WC)and 82371148(to WG);Fujian Provincial Healthcare Young and Middle-aged Backbone Talent Training Project,No.2023GGA035(to XC);Spring City Plan;the High-level Talent Promotion and Training Project of Kunming,No.2022SCP001(to SY);the Natural Science Foundation of Hainan Province of China,No.824MS052(to XS);the Sixth Medical Center of Chinese PLA General Hospital Innovation Cultivation,No.CXPY202116(to LX)。; Noise-induced hearing loss is the primary non-genetic factor contributing to auditory dysfunction.However,there are currently no effective pharmacological interventions for patients with noise-induced hearing loss.Her...; 关键词：4-HYDROXYNONENAL apoptosis AUTOPHAGY cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 TRANYLCYPROMINE

Electroacupuncture Promotes Gastric Motility by Suppressing Pyroptosis via NLRP3/Caspase-1/GSDMD Signaling Pathway in Diabetic Gastroparesis Rats: 《Chinese Journal of Integrative Medicine》2025年第5期448-457,共10页HUANG Hao PENG Yan XIAO Le WANG Jing XIN Yu-hong ZHANG Tian-hua LI Xiao-yu WEI Xing; Supported by the National Natural Science Foundation of China(No.81774431);Hunan Provincial Natural Science Foundation of China(No.2022JJ40310 and 2024JJ5306);Scientific Research Fund of Hunan Provincial Education Department(No.22A0275);Changsha Municipal Natural Science Foundation(No.kq2202263)。; Objective:To investigate the mechanism of electroacupuncture(EA)in treating diabetic gastroparesis(DGP)by inhibiting the activation of Nod-like receptor family pyrin domain-containing protein 3(NLRP3)inflammasome and ...; 关键词：ELECTROACUPUNCTURE diabetic gastroparesis PYROPTOSIS Nod-like receptor family pyrin domain-containing protein 3 cysteinyl aspartate specific proteinase-1 gasdermin D

AstragalosideⅣAlleviates Podocyte Injury in Diabetic Nephropathy through Regulating IRE-1α/NF-κB/NLRP3 Pathway: 《Chinese Journal of Integrative Medicine》2025年第5期422-433,共12页SUN Da-lin GUO Zi-yi LIU Wen-yuan ZHANG Lin ZHANG Zi-yuan HU Ya-ling LI Su-fen ZHANG Ming-yu ZHANG Guang WANG Jin-jing FANG Jing-ai; Supported by the International Cooperation Project of Department of Science and Technology of Shanxi Province(No.201903D421057);the Youth Fund Project of Department of Science and Technology of Shanxi Province(No.201901D211485)。; Objective:To investigate the effects of astragalosideⅣ(AS-Ⅳ)on podocyte injury of diabetic nephropathy(DN)and reveal its potential mechanism.Methods:In in vitro experiment,podocytes were divided into 4 groups,normal...; 关键词：diabetic nephropathy astragalosideⅣ PODOCYTE inositol-requiring enzyme 1α/nuclear factor kappa Bp65/NLR family pyrin domain containing 3 pathway

The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence: 《Neural Regeneration Research》2025年第4期1153-1163,共11页Susana Mellado María JoséMorillo-Bargues Carla Perpiñá-Clérigues Francisco García-García Victoria Moreno-Manzano Consuelo Guerri María Pascual; supported by grants from the Spanish Ministry of Health-PNSD(2019-I039 and 2023-I024)(to MP);FEDER/Ministerio de Ciencia e Innovación-Agencia Estatal de Investigación PID2021-1243590B-I100(to VMM);GVA(CIAICO/2021/203)(to MP);the Primary Addiction Care Research Network(RD21/0009/0005)(to MP);a predoctoral fellowship from the Generalitat Valenciana(ACIF/2021/338)(to CPC).; Our previous studies have reported that activation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with ...; 关键词：ADOLESCENCE binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD- LRR-and pyrin domain-containing protein 3(NLRP3)

人参皂苷Rg3通过RhoA/ROCK/NLRP3通路改善糖尿病肾病小鼠肾小球内皮损伤机制的实验研究: 《现代检验医学杂志》2025年第2期123-128,共6页刘美燕李娜赵淑洁郑倩倩霍云涛; 河北省中医药类科学研究课题计划项目(2024200)。; 目的探究人参皂苷Rg3是否可通过Ras同源基因家族成员A(RhoA)/RHO关联卷曲螺旋蛋白激酶(ROCK)/含NLR家族Pyrin域蛋白3(NLRP3)通路改善糖尿病肾病(DN)小鼠肾小球内皮损伤。方法将40只小鼠随机分为4组:对照组、DN组、人参皂苷(人参皂苷Rg3...; 关键词：糖尿病肾病肾小球内皮损伤人参皂苷RG3 Ras同源基因家族成员A/RHO关联卷曲螺旋蛋白激酶/含NLR家族Pyrin域蛋白3 细胞焦亡

RORγt、NLRP3、miR-3615水平检测在肺癌诊断中的价值分析: 《医学理论与实践》2025年第5期841-844,共4页郭子用; 目的:探究视黄酸受体相关孤儿受体γt(RORγt)、含NLR家族Pyrin域蛋白3(NLRP3)、miR-3615水平检测在肺癌诊断中的价值分析。方法:选取2020年3月—2023年3月我院收治的100例肺癌患者作为研究组。同一时间选择我院60例健康体检者作为对照...; 关键词：肺癌视黄酸受体相关孤儿受体γt 含NLR家族Pyrin域蛋白3 miR-3615

Transmembrane protein 176B promotes epithelial-mesenchymal transition in colorectal cancer through inflammasome inhibition: 《World Journal of Gastrointestinal Oncology》2025年第3期171-187,共17页Wei Qian Chong-Yi Xu Wei Hong Zhe-Ming Li Dao-Gun Xu; Ministry of Education Industry-University Co-operation Collaborative Education Project,No.202102242020.; BACKGROUND Activation of the epithelial-mesenchymal transition(EMT),a pivotal process in tumor metastasis and evasion,as well as the NLRP3 inflammasome,both promote colorectal cancer(CRC)progression.Recent studies hav...; 关键词：Transmembrane protein 176B Epithelial-mesenchymal transition Colorectal cancer Pyrin domain containing 3 inflammasome Natural killer cell

Involvement of the NLRP3/IL-1βpathway in activation and effector functions ofγδT17 cells in patients with ulcerative colitis: 《World Journal of Gastroenterology》2025年第12期82-90,共9页Jing Ma Feng-Yun Wang Xu-Dong Tang; Supported by China Academy of Chinese Medical Sciences Outstanding Young Talents(Innovative)Cultivation Project,No.ZZ17-YQ-007;Special Project of the National Natural Science Foundation of China,No.82341233.; BACKGROUND The interleukin-17(IL-17)mediated aberrant immune-inflammatory response plays a paramount role in ulcerative colitis(UC).γδT17 cells are one of the critical sources of IL-17,but the role they play in UC r...; 关键词：Ulcerative colitis Abnormal immune response γδT17 cells NLR family pyrin domain containing 3/interleukin-1βpathway Observational study

针药并用对子宫内膜异位症疼痛大鼠CLEC5A、NLRP3和IL-1β表达的影响: 《上海针灸杂志》2025年第3期355-365,共11页胡佳玮吴楚婷徐丹丹高源李云翼李铭旸李语然张春雁; 上海市“科技创新行动计划”启明星培育-扬帆专项(22YF1444200);上海市“科技创新行动计划”科技成果转化服务体系建设项目(23ZC2520700);国家自然科学基金青年项目(82405565);上海市东方英才计划青年项目;上海市卫生健康委员会卫生行业临床研究专项(202240054);金华市科学技术局重点项目(2024-3-140);上海中医药大学“杏林学者”;上海申康医院发展中心促进市级医院临床技能与临床创新能力三年行动计划项目(SHDC2020CR3093B)。; 目的观察针药并用对子宫内膜异位症疼痛大鼠CLEC5A、NLRP3和IL-1β表达的影响,探讨针药并用缓解子宫内膜异位症疼痛的作用机制。方法从48只大鼠随机选取8只进行假手术作为假手术组,剩余40只进行子宫内膜异位症造模,模型建立后根据异位...; 关键词：针药并用子宫内膜异位症疼痛 C型凝集素结构域家族5成员A NLR家族Pyrin域蛋白3 白细胞介素-1β 大鼠

Nucleotide-binding domain,leucine-rich repeat,and pyrin domaincontaining protein 3 inflammasome:From action mechanism to therapeutic target in clinical trials: 《World Journal of Gastrointestinal Oncology》2025年第2期6-16,共11页Chun-Ye Zhang Shuai Liu Yu-Xiang Sui Ming Yang; The nucleotide-binding domain,leucine-rich repeat,and pyrin domain-containing protein 3(NLRP3)inflammasome is a critical modulator in inflammatory disease.Activation and mutation of NLRP3 can cause severe inflammation...; 关键词：Nucleotide-binding domain leucine-rich repeat and pyrin domain-containing protein 3 Metabolic disease INFLAMMATION Cancer IMMUNOTHERAPY Clinical trial

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