supported by grants from the National Natural Science Foundation of China (No. 81430024; 31471114; 31500837; 31540075);the Higher Educational Science and Technology Program; Shandong Province; China (No. J15LE18)
supported by the Science Research Foundation of Ministry of Health of China-Pharmaceutical and Health Care Science and Technology Major Program of Zhejiang Province,China(No.WKJ2009-2-030);Traditional Chinese Medicine Key Discipline Construction Project of Zhejiang Province,China(No.2012-XK-A28)
supported by the National Basic Research Development Program of China(No.2012CB518200);the National Natural Science Foundation of China(No.31071002);the Natural Science Foundation of Hebei Province,China(No.C2012206001);the Science and Technology Program of Hebei Province,China(No.12276104D40,11246125D);the Medical Research Key Projectof Health Bureau of Hebei Province,China(No.20090319)
supported by National Heart, Lung, and Blood Institute Grant (No. HL-067890);National Institutes of Health Grant (No. HD060959);the American Heart Association (No. 09GRNT2010037)
supported by the National Natural Science Foundation of China(No.30572086;31071002);the National Basic Research Program of China(No.2006CB504100);the Research Fund for the Doctoral Program of Higher Education of China(No.20060089009);the Key Medicine Research Projects of Hebei Health Bureau;China(No.20090319)