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Biosynthesis of clinically used antibiotic fusidic acid and identification of two short-chain dehydrogenase/reductases with converse stereoselectivity被引量：4
《Acta Pharmaceutica Sinica B》2019年第2期433-442,共10页Zhiqin Cao Shaoyang Li Jianming Lv Hao Gao Guodong Chen Takayoshi Awakawa Ikuro Abe Xinsheng Yao Dan Hu 
supported by grants from the National Natural Science Foundation of China(31870032,3171101305,and 31670036);the 111 Project of Ministry of Education of the People's Republic of China(B13038);the JST/NSFC Strategic International Collaborative Research Program;Japanese-Chinese Collaborative Research Program;Chang Jiang Scholars Program(Hao Gao,2017)from the Ministry of Education of China;Guangdong Special Support Program(2016TX03R280);Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme(Hao Gao,2014);K.C.Wong Education Foundation(Hao Gao,2016);Guangzhou Science and Technology Project(201707010266,China);the Fundamental Research Funds for the Central Universities(21617495);Kobayashi International Scholarship Foundation;a Grant-in-Aid for Scientific Research from the Ministry of Education,Culture,Sports,Science and Technology,Japan(JSPS KAKENHI Grant Number JP15H01836 and JP16H06443)
Fusidic acid is the only fusidane-type antibiotic that has been clinically used. However,biosynthesis of this important molecule in fungi is poorly understood. We have recently elucidated the biosynthesis of fusidane-...
关键词：BIOSYNTHESIS FUNGI Fusidic acid Fusidane-type ANTIBIOTICS SDR 
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