CORONAVIRUS

作品数：670被引量：1624H指数：19
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The structural and accessory proteins M,ORF 4a,ORF 4b,and ORF 5 of Middle East respiratory syndrome coronavirus(MERS-CoV)are potent interferon antagonists被引量：25
《Protein & Cell》2013年第12期951-961,共11页Yang Yang Ling Zhang Heyuan Geng Yao Deng Baoying Huang Yin Guo Zhengdong Zhao Wenjie Tan 
This work was supported by the National Basic Research Program(973 Program)(No.2011CB504704);the Ministry of Health of China(2014ZX10004-001,2013ZX10004601).
The newly emerged Middle East respiratory syndrome coronavirus(MERS-CoV)is a highly pathogenic respira-tory virus with pathogenic mechanisms that may be driven by innate immune pathways.The goal of this study is to ch...
关键词：MERS-CoV structural proteins accessory proteins interferon antagonists 
The newly emerged SARS-Like coronavirus HCoV-EMC also has an “Achilles’ heel”: current effective inhibitor targeting a 3C-like protease被引量：11
《Protein & Cell》2013年第4期248-250,共3页Zhilin Ren Liming Yan Ning Zhang Yu Guo Cheng Yang Zhiyong Lou Zihe Rao 
supported by the National Basic Research Program(973 Program);National Natural Science Foundation of China.
From the global outbreak of SARS-CoV caused infection disease in 2003,coronaviruses(CoVs)are known to be a great threat to the human health.Recently,a new SARS-like coronavirus,human betacoronavirus 2c EMC/2012(HCoV-E...
关键词：EMC SARS Together 
Structures of the N- and C-terminal domains of MHV-A59 nucleocapsid protein corroborate a conserved RNA-protein binding mechanism in coronavirus被引量：3
《Protein & Cell》2010年第7期688-697,共10页Yanlin Ma Xiaohang Tong Xiaoling Xu Xuemei Li Zhiyong Lou Zihe Rao 
supported by the National Natural Science Foundation of China(Grant No.30730022);the National Basic Research Program(973 Program)(Grant No.2006CB806503);the National Programs for High Technology Research and Development Program(863 Program)(Grant Nos.2006AA02A322 and 2006AA020502);the National Major Project(Grant No.2009ZX10004-304);the Chinese Academy of Sciences Grant KSCX2-YW-R-05 to Z.R.
Coronaviruses are the causative agent of respiratory and enteric diseases in animals and humans.One example is SARS,which caused a worldwide health threat in 2003.In coronaviruses,the structural protein N(nucleocapsid...
关键词：crystal structure nucleocapsid protein murine hepatitis virus 
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