CYTOCHROME_P450

作品数：271被引量：809H指数：13
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Shenzhuo formulation ameliorates diabetic nephropathy by regulating cytochrome P450-mediated arachidonic acid metabolism
《World Journal of Diabetes》2025年第5期331-345,共15页Zhong-Yong Zhang Yu-Ming Wang Ning Wang Yuan-Song Wang Hui Zhang Duo Wang Li-Xin Wang Huan-Tian Cui Wei-Bo Wen Shu-Quan Lv Yong-Jun Cao 
Supported by the Natural Science Foundation of Hebei Province Beijing-Tianjin-Hebei Basic Research Special Program,No.H2020110287;Key Laboratory for Diabetic Kidney Disease Syndrome and Treatment of the Traditional Chinese Medicine Administration of Hebei Province,No.7[2024];Yuansong Wang National Famous Traditional Chinese Medicine Expert Heritage Studio,No.3[2024];Hebei Key Laboratory of Integrated Traditional Chinese and Western Medicine for Diabetes and Its Complications,No.SZX2020015;Jiangsu Province Chinese Medicine Science and Technology Development Program Project,No.YB2020065.
BACKGROUND Diabetic nephropathy(DN)is a major complication of diabetes,marked by progressive renal damage and an inflammatory response.Although research has investigated the pathological mechanisms underlying DN,effec...
关键词：Diabetic nephropathy Shenzhuo formulation TRANSCRIPTOMIC METABOLOMIC Cytochrome P450 Arachidonic acid metabolic INFLAMMATORY Oxidative stress 
Cytochrome P450 Enzyme Design by Constraining the Catalytic Pocket in a Diffusion Model
《Research》2025年第1期618-630,共13页Qian Wang Xiaonan Liu Hejian Zhang Huanyu Chu Chao Shi Lei Zhang Jie Bai Pi Liu Jing Li Xiaoxi Zhu Yuwan Liu Zhangxin Chen Rong Huang Hong Chang Tian Liu Zhenzhan Chang Jian Cheng Huifeng Jiang 
funding from the National Key R&D Program of China(grant no.2019YFA0905700 and 2021YFC2103500);the National Natural Science Foundation of China(no.32371499);the China Postdoctoral Science Foundation(grant no.2019M661032);the National Natural Science Foundation of China(NSFC,grant nos.31901026 and 32171418);the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project(nos.TSBICIP-KJGG-002-02 and TSBICIP-CXRC-015);the Tianjin Science Fund for Distinguished Young Scholars(no.18JCJQJC48300).
Although cytochrome P450 enzymes are the most versatile biocatalysts in nature,there is insufficient comprehension of the molecular mechanism underlying their functional innovation process.Here,by combining ancestral ...
关键词：cytochrome P progressive forward accumulationwe cytochrome p enzymes molecular mechanism ancestral sequence reconstructionreverse mutation assayand de novo design catalytic pocket functional innovation 
Decoding the mechanism of P450-catalyzed aromatic hydroxylation:Uncovering the arene oxide pathway and insights into the regioselectivity
《Chinese Journal of Catalysis》2025年第3期420-430,共11页Qun Huang Xuan Zhang Guangwu Sun Rui-ying Qiu Lan Luo Cuizhen Wang Longwei Gao Bing Gao Bo Chen Binju Wang Jian-bo Wang 
国家重点研发计划(2023YFA0914100/2023YFA0914102);国家自然科学基金(22077029,22477110,22034002,22276049,22073077,22001065);中央高校基本科研业务费(226202400061,226202300100);湖南省杰出青年科学基金(2021JJ10034);重庆市教委科学技术研究项目(KJQN202401148);植化单体开发与利用湖南省重点实验室开放基金(23010104).
P450 enzymes-catalyzed aromatic hydroxylation plays an important role in detoxification,biosynthesis,and potential carcinogenic effect of aromatic compounds.Though it has been explored for decades,the actual process o...
关键词：Aromatic hydroxylation Cytochrome P450 Arene oxide Regioselectivity DEAROMATIZATION 
MePHD1.2 affects the synthesis of cyanogenic glycosides by regulating transcription of MeCYP79D2 in cassava
《The Crop Journal》2025年第1期204-214,共11页Mengtao Li Xiao Zhao Yajun Li Yuanchao Li Xiaoye Zhao Weitao Mai Luqman Khan Qibing Liang Qingchun Yin Wenquan Wang Jinping Liu Xin Chen 
supported by grants from the National Natural Science Foundation of China(32460505);China Agriculture Research System(CARS-11);the Chinese Academy of Tropical Agricultural Sciences for the Science and Technology Innovation Team of the National Tropical Agricultural Science Center(CATASCXTD202301);Additional support was provided by the Hainan Province Graduate Innovation Research Project(Hyb2020-09);the Key Laboratory of Tropical Fruits and Vegetables Quality and Safety for State Market Regulation(KF-2023016).
The high content of cyanogenic glycosides(CG)in cassava tubers affects food safety.CG are involved in the plant growth and development and protect cassava leaves from herbivorous predators.However,the regulatory mecha...
关键词：Cyanogenic glycosides Cytochrome P450 Manihot esculenta MePHD1.2 
P450 gene CYP321A8 is responsible for cross-resistance of insecticides in field populations of Spodoptera frugiperda
《Insect Science》2025年第1期227-242,共16页Yumei Chen Yongjie Cen Yu Liu Yanan Peng Yiguang Lin Qili Feng Yong Xiao Sichun Zheng 
supported by the National Key R&D Program of China(No.2021YFD1400704);Guangdong Province Basic and Applied Basic Research Foundation of China(No.2022A1515012601).
Continuous and long-term use of traditional and new pesticides can result in cross-resistance among pest populations in different fields.Study on the mechanism of cross-resistance and related genes will help resistanc...
关键词：CROSS-RESISTANCE cytochrome P450 field population insecticide resistance Spodoptera frugiperda 
Catalytic performances of engineered and artificial heme peroxygenases
《Chinese Journal of Catalysis》2025年第2期35-51,共17页Yiping Jiang Zaw Ko Latt Zhiqi Cong 
科技部国家重点研发计划(2023YFA0915500);国家自然科学基金(32371311,32471325,22207112);泰山学者项目;中国科学院国际人才计划(2019PB0167);中国科学院青岛生物能源与过程研究所自主部署项目(S202302).
Heme peroxygenases exhibit remarkable catalytic versatility in facilitating a wide array of oxidative reactions under mild conditions,eliminating the need for coenzymes and intricate electron transport systems.This un...
关键词：Peroxygenases Hydrogen peroxide Cytochrome P450 peroxygenases Unspecific peroxygenases Protein engineering 
Cyt02 encodes cytochrome P450 monooxygenase,increasing rice(Oryza sativa L.)resistance to sheath blight被引量：1
《The Crop Journal》2025年第1期92-103,共12页Tengda Zheng Xiaolin Wang Yuewen He Deqiang Li Andrews Danso Ofori Xing Xiang Abdul Ghani Kandhro Xiaoqun Yi Fu Huang Jianqing Zhu Ping Li Aiping Zheng 
supported by the Sichuan Province International Science and Technology Innovation Cooperation(2024YFHZ0299);the Project of Science and Technology Department of Sichuan Province(2022YFH0031);Chengdu Science and Technology Bureau(2024-YF05-02168-SN).
Rice sheath blight(RSB)is a major destructive disease impeding rice production.Identifying key germplasm resources with increased resistance remains a challenge.However,the mechanisms underlying disease resistance are...
关键词：RICE Sheath blight Cytochrome P450 monooxygenase Metabolomics analysis Functional analysis 
Furanocoumarin profiles and inhibitory effects on cytochrome P450 activity of whole citrus fruit
《Food Quality and Safety》2024年第4期684-694,共11页Yujing Sun Yihua Wang Le Zhang Xingqian Ye Jingtong Guo 
supported by the corporate-funded project(KYY-HX-20230378);the National Natural Science Foundation of China(No.31771982).
Furanocoumarins in citrus fruit can cause adverse drug interactions;however,there are few reports on furanocoumarins and drug interactions in common edible citrus cultivars except grapefruit.An ultra-performance liqui...
关键词：Citrus fruit PULP PEEL FURANOCOUMARINS cytochrome P450 
Functional analysis of the whole CYPome and Fdxome of Streptomyces venezuelae ATCC 15439
《Engineering Microbiology》2024年第4期12-23,共12页Shuai Li Zhong Li Guoqiang Zhang Vlada BUrlacher Li Ma Shengying Li 
This work was supported by the National Natural Science Foundation of China(32025001,32071266 and 32200017);the Shandong Provin-cial Natural Science Foundation(ZR2022QC070 and ZR2019ZD20).
Cytochrome P450 enzymes(CYPs or P450s)and ferredoxins(Fdxs)are ubiquitously distributed in all domains of life.Bacterial P450s are capable of catalyzing various oxidative reactions with two electrons usually donated b...
关键词：STREPTOMYCES Cytochrome P450 enzymes CYPome FERREDOXIN Fdxome PikC 
Design and engineering of logic genetic-enzymatic gates based on the activity of the human CYP2C9 enzyme in permeabilized Saccharomyces cerevisiae cells
《Synthetic and Systems Biotechnology》2024年第3期406-415,共10页Rana Azeem Ashraf Matthias Bureik Mario Andrea Marchisio 
Gene circuits allow cells to carry out complex functions such as the precise regulation of biological metabolic processes.In this study,we combined,in the yeast S.cerevisiae,genetic regulatory elements with the enzyma...
关键词：Cytochrome P450 Drug metabolism Budding yeast DICLOFENAC Synthetic biology CORM-401 Boolean gates 
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