This work was supported by the National Natural Science Foundation of China(32192423).
Two emerging studies published in Nature back to back reported the cryo-electron microscopy(cryo-EM)structures of Dicer complexes in the double-stranded RNA(dsRNA)-processing cycle,providing detailed mechanistic insig...
NationalNatural Science Foundation of China,Grant/Award Numbers:81672440,31701156,81972625;DICP,Grant/Award Number:ZZBS201803;The Construction of Liaoning CancerResearch Center,Grant/Award Number:1564992449013。
Background:Y-box binding protein 1(YB1 or YBX1)plays a critical role in tumorigenesis and cancer progression.However,whether YB1 affects malignant transformation by modulating non-codingRNAs remains largely unknown.Th...
This work was supported by the National Natural Science Foundation of China(81922032,31900660,81788101);the Young Elite Scientist Sponsorship Program by CAST(2018QNRC001).
Background:Small RNAs(sRNAs)extensively mediate gene-specific chromatin regulation in lower organisms.As a dominant type of functional sRNAs in mature mammals,microRNAs mainly regulate gene expression at posttranscrip...
Cullin-RING ligases(CRLs)comprise a large group of modular eukaryotic E3 ubiquitin ligases.Within this family,the CRL4 ligase(consisting of the Cullin4[CUL4]scaffold protein,the Rbxl RING finger domain protein,the DNA...