DIFFERENTIATION

作品数:1501被引量:4961H指数:25
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相关领域:医药卫生更多>>
相关作者:崔克明李琰王雅清贺新强谭洁琼更多>>
相关机构:北京大学清华大学中国科学院浙江大学医学院附属第二医院更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
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Inhibition of aryl hydrocarbon receptor signaling promotes the terminal differentiation of human erythroblasts被引量:1
《Journal of Molecular Cell Biology》2022年第2期18-31,共14页Yijin Chen Yong Dong Xulin Lu Wanjing Li Yimeng Zhang Bin Mao Xu Pan Xiaohong Li Ya Zhou Quanming An Fangxin Xie Shihui Wang Yuan Xue Xinping Cai Mowen Lai Qiongxiu Zhou Yan Yan Ruohan Fu Hong Wang Tatsutoshi Nakahata Xiuli An Lihong Shi Yonggang Zhang Feng Ma 
supported by the National Basic Research Program(973 Program,2015CB964902);the National Natural Science Foundation of China(H81170466 and H81370597);the CAMS Initiatives for Innovative Medicine(2016-I2M-1-018,2019-I2M-1-006,and 2017-I2M-2005)to F.M.,the National Natural Science Foundation of China Youth Fund(82000119)to Yonggang Zhang.
The aryl hydrocarbon receptor(AHR)plays an important role during mammalian embryo development.Inhibition of AHR signaling promotes the development of hematopoietic stem/progenitor cells.AHR also regulates the function...
关键词:ERYTHROBLAST AHR SR-1 human pluripotent stem cells DIFFERENTIATION 
TAPP1 inhibits the differentiation of oligodendrocyte precursor cells via suppressing the Mek/Erk pathway被引量:1
《Neuroscience Bulletin》2015年第5期517-526,共10页Yidan Chen Ruyi Mei Peng Teng Aifen Yang Xuemei Hu Zunyi Zhang Mengsheng Qiu Xiaofeng Zhao 
supported by the National Natural Sciences Foundation of China (31471955 and 31372150);the National Basic Research Development Program (973 Program) of China (2013CB531300)
Oligodendrocytes(OLs) are glial cells that form myelin sheaths around axons in the central nervous system(CNS).Loss of the myelin sheath in demyelinating and neurodegenerative diseases can lead to severe impairmen...
关键词:TAPP1 differentiation oligodendrocyte spinal cord 
ISOLATION AND INDUCTION OF DIFFERENTIATION OF SEINE ADIPOSE-DERIVED MESENCHYMAL STEM CELLS
《Journal of Otology》2014年第2期101-105,共5页MA Yueying YUAN Shuolong ZHANG yue XU liangwei GUO Weiwei ZHAO Lidong ZHAI suoqiang YANG Shiming 
supported by grants from the National Basic Research Program of China(973Program)(2012CB967900;2012CB967901)
Objectives To establish a method for high yield mesenchymal stem cells collection, as well as a culture method for iden- tifying mesenchymal stem cells from the swine adipose-derived mesenchymal stem cell (ADMSC). M...
关键词:Adipose-derived mesenchymal stem cell DIFFERENTIATION Transplantation Osteogenic cell  Adipogenic cell Chondrogrnic cell 
Reconstitution of Gametogenesis In Vitro:Meiosis Is the Biggest Obstacle被引量:5
《Journal of Genetics and Genomics》2014年第3期87-95,共9页Yuan-Chao Sun Shun-Feng Cheng Rui Sun Yong Zhao Wei Shen 
supported by the National Basic Research Program of China(973 Program)(Grant Nos.2013CB947903 and 2012CB944401);Program for New Century Excellent Talents in University of China(Grant No.NCET-12-1026);Foundation of Distinguished Young Scholars of Shandong Province in China(Grant No.JQ201109)
Germ-line cells are responsible for transmitting genetic and epigenetic information across generations, and ensuring the creation of new individuals from one generation to the next. Gametogenesis process requires seve...
关键词:Stem cells Germ cells GAMETOGENESIS DIFFERENTIATION MEIOSIS 
Vitamin C induces periodontal ligament progenitor cell differentiation via activation of ERK pathway mediated by PELP1被引量:7
《Protein & Cell》2013年第8期620-627,共8页Yan Yan Wenfeng Zeng Shujun Song Fayun Zhang Wenxi He Wei Liang Zhongying Niu 
This work is supported by grants:the National Basic Research Program(973 Program)(No.2011CB707705);National Natural Science Foundation of China(Grant No.11202229).
The differentiation of periodontal ligament(PDL)progenitor cells is important for maintaining the homeostasis of PDL tissue and alveolar bone.Vitamin C(VC),a water-soluble nutrient that cannot be biosynthesized by hum...
关键词:periodontal ligament progenitor cells Vitamin C PELP1 ERK signaling pathway osteogenic differentiation 
Characterization of human primary chondrocytes of osteoarthritic cartilage at varying severity
《Chinese Medical Journal》2011年第24期4245-4253,共9页YIN Jing YANG Zheng CAO Yong-ping GE Zi-gang 
This work is supported by National Basic Research Program of China (973 Program) (No. 2011CB707500, 2012CB619102) and National Natural Science Foundation of China (No. 30772198, 30970881, 31011140348).
Background There is a difficulty in evaluating the in heterogeneity among cartilage affected by osteoarthritis vivo functionality of individual chondrocytes, and there is much (OA). In this study, in vitro cultured ...
关键词:OSTEOARTHRITIS chondroeyte DIFFERENTIATION 
Transformation of human amniotic epithelial cells into neuron-like cells in the microenvironment of traumatic brain injury in vivo and in vitro被引量:10
《Neural Regeneration Research》2011年第10期744-749,共6页Yi Lu Guozhen Hui Zhiyuan Wu Tianjin Liu Xunhe Ji Lihe Guo 
the Grant from National Basic Research Program of China (973 Program) for Traumatic Projects, No. 2005CB522604
Survival and differentiation of transplanted cells is closely related to the local microenvironment.The present study cultured human amniotic epithelial cells(HAECs) in a simulated microenvironment in vitro comprisi...
关键词:traumatic brain injury MICROENVIRONMENT TRANSPLANTATION human amniotic epithelialcells neural cell differentiation neural regeneration 
Contribution of cancer stem cells to tumor vasculogenic mimicry被引量:19
《Protein & Cell》2011年第4期266-272,共7页Xiao-hong Yao Yi-fang Ping Xiu-wu Bian 
the National Basic Research Program of China(973 Program)(Grant No.2010CB529403);National Natural Science Foundation of China(Grant Nos.30800421,30725035 and 30930103).
Vasculogenic mimicry(VM),a newly-defined pattern of tumor blood supply,provides a special passage without endothelial cells and is conspicuously different from angiogenesis and vasculogenesis.The biological features o...
关键词:cancer stem cell vasculogenic mimicry differentiation plasticity NICHE MICROENVIRONMENT 
Development of a Highly Informative Microsatellite (SSR) Marker Framework for Rice (Oryza sativa L.) Genotyping被引量:5
《Agricultural Sciences in China》2010年第12期1697-1704,共8页JIANG Shu-kun HUANG Cheng ZHANG Xi-juan WANG Jia-yu CHEN Wen-fu XU Zheng-jin 
supported by the National Natural Science Foundation of China (30871468);the National Basic Research Program of China (973 Program,2009CB126007)
To select highly informative microsatellite markers (SSRs) and establish a useful genetic SSR framework for rice genotyping, 15 rice (Oryza sativa L.) cultivars including six indica varieties and nine japonica var...
关键词:SSR marker core primers rice variety differentiation diversity analysis genetic mapping 
Effect of gastrin on differentiation of rat intestinal epithelial cells in vitro被引量:9
《World Journal of Gastroenterology》2003年第8期1786-1790,共5页ZhouWang Wei-WenChen Ru-LiuLi BinWen Jing-BoSun 
the Major State Basic Research Development Program of China(973 Program)No.GI9990544;the National Natural Science Foundation of China,No.39970906
AIM: To investigate the effect of gastrin on differentiation of IEC-6 cell line in vitro.METHODS: IEC-6 cells were incubated with gastrin. On day 7 after treatment, cell morphology was examined by light microscope, an...
关键词:肠上皮细胞 胃泌激素 绒毛蛋白 体外试验 
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