云南高校图书馆联盟文献共享服务平台- ESSENTIAL

ESSENTIAL: 作品数：798被引量：1986H指数：20; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：陈汐敏丁贵鹏接雅俐唐震邹建刚更多>>; 相关机构：中国科学院复旦大学北京大学南京大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家社会科学基金更多>>

Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis被引量：2: 《National Science Review》2022年第7期10-24,共15页Yujuan Jin Qiqi Zhao Weikang Zhu Yan Feng Tian Xiao Peng Zhang Liyan Jiang Yingyong Hou Chenchen Guo Hsinyi Huang Yabin Chen Xinyuan Tong Jiayu Cao Fei Li Xueliang Zhu Jun Qin Dong Gao Xin-Yuan Liu Hua Zhang Luonan Chen Roman KThomas Kwok-Kin Wong Lei Zhang Yong Wang Liang Hu Hongbin Ji; the National Natural Science Foundation of China(81871875 and 82173340 to L.H.,82030083,81872312,82011540007 and 31621003 to H.J.,81402371 to Y.J.,12025107 to Y.W.);the National Basic Research Program of China(2017YFA0505501 and 2020YFA0803300 to H.J.);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB19020201 to H.J.);the Basic Frontier Scientific Research Program of the Chinese Academy of Sciences(ZDBSLY-SM006 to H.J.);the International Cooperation Project of the Chinese Academy of Sciences(153D31KYSB20190035 to H.J.);the Innovative Research Team of High-Level Local Universities in Shanghai(SSMU-ZLCX20180500 to H.J.);the Science and Technology Commission of Shanghai Municipality(21ZR1470300 to L.H.).; Small-cell lung cancer(SCLC)is a recalcitrant cancer characterized by high metastasis.However,the exact cell type contributing to metastasis remains elusive.Using a Rb1^(L/L)/Trp53^(L/L) mouse model,we identify the NC...; 关键词：small cell lung cancer SWI/SNF complex TAZ phenotypic transition METASTASIS

ROS is essential for initiation of energy deprivation-induced autophagy被引量：2: 《Journal of Genetics and Genomics》2021年第6期512-515,共4页Choufei Wu Yixing Li Shu Zhong Yingcong Chen Yu Xie Yuyao Feng Weijing Yao Suping Fu Yanlan Zhu Liefeng Wang Yuting Chen Liqin Zhang Jingjing Tong Cong Yi; supported by the National Natural Science Foundation of China(32070739,31771528,and 91754107);Zhejiang Provincial Natural Science Foundation of China(LR21C070001);the National Basic Research Program of China(2017YFA0503402)to C.Yi;Natural Science Foundation for Young Scientists of China(81800085);Natural Science Foundation of Hubei Province,China(ZRMS2020002147)to J.Tong;Zhejiang Key R&D Program of China(2019C02030)to L.Zhang。; Autophagy is a highly conserved degradation process in which intracellular components are engulfed into a double membrane structure,known as the autophagosomes,and then delivered to lysosomes/vacuoles for degradation(...; 关键词：DEPRIVATION HOMEOSTASIS

Study on the Biological Basis of Hypertension and Syndrome with Liver-Fire Hyperactivity Based on Data Mining Technology被引量：1: 《World Journal of Traditional Chinese Medicine》2018年第4期176-180,共5页Xue-Ling Ma Xing Zhai Jing-Wei Liu Xiao-Xing Xue Shu-Zhen Guo Hua Xie Jian-Xin Chen Hui-Hui Zhao Wei Wang; supported by the National Natural Science Foundation of China (81503382), (81603499), (81473521);the National Basic Research Program of China (973 Program) under Grant No.2011CB505106;scientific research project of Beijing University of Chinese Medicine (2015-JYB-JSMS036) and (2018-JYB-XJQ009); Objective: To construct gene co-occurrence network of hypertension and liver-fire hyperactivity syndrome, to investigate the biological basis of hypertension and liver-fire hyperactivity syndrome and the characteristi...; 关键词：Biological basis data mining ESSENTIAL HYPERTENSION gene chip liver-fire HYPERACTIVITY SYNDROME

CD146 is essential for PDGFRβ-induced pericyte recruitment被引量：10: 《Protein & Cell》2018年第8期743-747,共5页Jianan Chen Yongting LUO Hongxin Huang Shuilong Wu Jing Feng Jingjing Zhang Xiyun Yan; This work was supported by the National Basic Research Program of China （973 Programs, 2015CB553705, 2014CBA02003）, the National Natural Science Foundation of China （Grant Nos. 31370824, 31771628, 81371025, 91529306, 81371330, 91640112, 31670185, 81527805, 81671851, and 81502547）, Guangdong Natural Science Fund for Distinguished Young Scholars （2017A030306024）, and China and Novo Nordisk-CAS Research Fund （NNCAS-2015-11 ）.; Dear Editor, The homeostasis of the central nervous system （CNS） is regulated through the blood-brain barrier （BBB）, a protective barrier between the peripheral blood and the brain （Zhao et al., 2015）. As vascul...

Lipophagy is essential for lipid metabolism in fish被引量：1: 《Science Bulletin》2018年第14期879-882,共4页Jing wang Si-Lan Han Ling-Yu Li Dong-Liang Lu Samwel Mchele Limbu Dong-Liang Li Mei-Ling Zhang Zhen-Yu Du; supported by the National Basic Research Program of China(2014CB138603); Lipophagy is a form of autophagy in mammals.In this cellular process,lipid droplets(LDs)are degraded through the lysosomal degradative pathway[1].During lipophagy,LDs sequestrated in autophagosomes are delivered to ly...; 关键词：类脂化合物新陈代谢鱼哺乳动物生物功能脊椎动物 ing LD

An essential role for PNLDC1 in piRNA 3＇ end trimming and male fertility in mice被引量：4: 《Cell Research》2017年第11期1392-1396,共5页Yue Zhang Rui Guo Yiqiang Cui Zhiping Zhu Yingwen Zhang Hao Wu Bo Zheng Qiuling Yue Shun Bai Wentao Zeng Xuejiang Guo Zuomin Zhou Bin Shen Ke Zheng Mingxi Liu Lan Ye Jiahao Sha; This work was supported by the National Key R＆D Program of China （2016YFA0500902 and 2017YFA0103803）, the National Basic Research Program of China （2015CB943003）, National Natural Science Foundation of China Grant （81471502, 31771651, 31471228）, Excellent Youth Foundation of Jiangsu Scientific Committee（grant BK20150047）, and Innovative and Entrepreneurial Program of Jiangsu Province. We thank Jingdi Hu （Shanghai Biotechnology Corporation, Shanghai, China） for smalt RNA analysis.; Dear Editor, PIWI-interacting RNAs （piRNAs） are germ cell-specific small non-coding RNAs that are essential for silenc- ing transposable elements. Substantial efforts in the past decade have led to an understanding...

The polyketide synthase OsPKS2 is essential for pollen exine and Ubisch body patterning in rice被引量：14: 《Journal of Integrative Plant Biology》2017年第9期612-628,共17页Xiaolei Zhu Jing Yu Jianxin Shi Takayuki Tohge Alisdair R.Fernie Sagit Meir Asaph Aharoni Dawei Xu Dabing Zhang Wanqi Liang; supported by funds from the National Key Research and Development Program of China(No.2016YFD0101107);the National Key Basic Research Developments Program of the Ministry of Science and Technology of China(No.2013CB126902);the National Natural Science Foundation of China(No.31322040,31670309);the Innovative Research Team of the Ministry of Education and the 111 Project(No.B14016); Lipid and phenolic metabolism are important for pollen exine formation. In Arabidopsis, polyketide synthases （PKSs） are essential for both sporopollenin biosynthesis and exine formation. Here, we characterized the r...; 关键词：PKS The polyketide synthase OsPKS2 is essential for pollen exine and Ubisch body patterning in rice Figure

N-terminal domains of ARC1 are essential for interaction with the N-terminal region of Exo70A1 in transducing self-incompatibility of Brassica oleracea被引量：3: 《Acta Biochimica et Biophysica Sinica》2016年第9期777-787,共11页Songmei Shi Qiguo Gao Jing Zeng Xiaohuan Liu Quanming Pu Guixi Liu Hecui Zhang Xiaohong Yang Liquan Zhu; This work was supported by the grants from the Chongqing Natural Science Foundation （cstc2012jjB80010）, the National Natural Science Foundation of China （Nos. 30900986, 30971849, and 31572127）, and the National Basic Research Program of China （2012CB113900）.; Self-incompatibility （Sl） is an important mating system to prevent inbreeding and promote out- crossing. ARC1 and Exo70A1 function as the downstream targets of the S-locus receptor kinase and play conservative roles...; 关键词：Brassicaceae structure analysis TRUNCATION UBIQUITINATION U-BOX

Signature motif-guided identification of receptors for peptide hormones essential for root meristem growth被引量：30: 《Cell Research》2016年第6期674-685,共12页Wen Song Li Liu Jizong Wang Zhen Wu Heqiao Zhang Jiao Tang Guangzhong Lin Yichuan Wang Xing Wen Wenyang Li Zhifu Han Hongwei Guo Jijie Chai; Acknowledgments We thank S Huang and J He at Shanghai Synchrotron Radiation Facility （SSRF） for assistance with data collection; H Deng and J Liu at the center for Biomedical Analysis of Tsinghua University for MS analysis; L Li and A Jiang at Peking University for pro- viding the incubator. We acknowledge the Tsinghua University Branch of China National Center for Protein Sciences Beijing for providing the facility support. This work was funded by Projects of International Cooperation and Exchanges of the National Natural Science Foundation of China （31420103906）, the Ministry of Science and Technology of China （2015CB910200） and State Key Program of the National Natural Science of China （31130063 and 31421001） to JC; the National Natural Science Foundation of Chi- na （91217305 and 91017010） to HG.; Peptide-mediated cell-to-cell signaling has crucial roles in coordination and definition of cellular functions in plants. Peptide-receptor matching is important for understanding the mechanisms underlying peptide-medi...; 关键词：peptide hormone RAM RGF receptor crystal structure RxR motif

Effect of direct moxibustion on blood pressure and clinical symptoms in elderly patients with essential hypertension被引量：5: 《Journal of Acupuncture and Tuina Science》2016年第2期73-81,共9页李垠和周次利赵天平陈咸川程玲刘慧荣吴焕淦马晓芃; supported by the Program of Shanghai Municipal Health Bureau(No.20134093);National Basic Research Program of China 973 Program(No.2009CB522900)~~; Objective： To assess the effects of direct moxibustion on 24-hour ambulatory blood pressure （ABP） and clinical symptoms of traditional Chinese medicine （TCM） in elderly patients with essential hypertension, and t...; 关键词：Moxibustion Therapy Direct Moxibustion Moxa Cone Moxibustion Hypertension Essential Blood PressureMonitoring Ambulatory Aged

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

ESSENTIAL

检索结果分析

下载全文

高级检索检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

ESSENTIAL

检索结果分析

下载全文

用户登录

高级检索检索式检索