supported by“Strategic Priority Research Program”of the Chinese Academy of Sciences[XDA16010309];National Key Research and Development Programs of China[2018YFA0108003];the National Science Foundation for Young Scientists of China[81901094];grants from the Ministry of Science and Technology of China(2017YFA0104002)。
The apolipoprotein E4(APOE4)genotype is one of the strongest genetic risk factors for Alzheimer’s disease(AD),and is generally believed to cause widespread pathological alterations in various types of brain cells.Her...