by the National Basic Research Program(973 Program)(Nos.2006CB806503,2007CB914301 and 2007CB914304);the National Programs for High Technology Research and Development Program(863 Program)(No.2006AA02A322);the National Major Project(Grant No.2009ZX10004-304).
The human Gadd45 protein family plays critical roles in DNA repair,negative growth control,genomic stability,cell cycle checkpoints and apoptosis.Here we report the crystal structure of human Gadd45,revealing a unique...