IFN-Β

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Zika virus non-structural protein 4B interacts with DHCR7 to facilitate viral infection
《Virologica Sinica》2023年第1期23-33,共11页Weijie Chen Yukun Li Xiuling Yu Zhenwei Wang Wenbiao Wang Menglan Rao Yongkui Li Zhen Luo Qiwei Zhang Jinbiao Liu Jianguo Wu 
supported by the National Natural Science Foundation of China(81730061,81802008);the Guangdong Basic and Applied Basic Research Foundation(2021A1515011272).
Zika virus(ZIKV)evolves non-structural proteins to evade immune response and ensure efficient replication in the host cells.Cholesterol metabolic enzyme 7-dehydrocholesterol reductase(DHCR7)was recently reported to im...
关键词：7-Dehydrocholesterol reductase(DHCR7) Interferon regulatory factor 3(IRF3) Interferon-beta(IFN-β) Non-structural protein 4B(NS4B) TANK-Binding kinase 1(TBK1) Zika virus(ZIKV) 
IFN-β1b induces OAS3 to inhibit EV71 via IFN-β1b/JAK/STAT1 pathway被引量：3
《Virologica Sinica》2022年第5期676-684,共9页Baisong Zheng Xiaolei Zhou Li Tian Jian Wang Wenyan Zhang 
supported by funding from the National Key R&D Program of China (2021YFC2301900 and 2301904);National Natural Science Foundation of China (81930062);Science and Technology Department of Jilin Province (YDZJ202201ZYTS590);Health Commission of Jilin Province (2020J059);the Key Laboratory of Molecular Virology,Jilin Province (20102209)
Enterovirus 71(EV71) caused hand, foot and mouth disease(HFMD) is a serious threat to the health of young children. Although type I interferon(IFN-I) has been proven to control EV71 replication, the key downstream IFN...
关键词：Enterovirus 71(EV71) 20-50-oligoadenylate synthetases 3(OAS3) RNase L IFN-β1b JAK/STAT 
Proteasome Inhibitor PS-341 Effectively Blocks Infection by the Severe Fever with Thrombocytopenia Syndrome Virus被引量：4
《Virologica Sinica》2019年第5期572-582,共11页Sihua Liu Hongyun Liu Keke Zhang Xueping Li Yuqin Duan Zhiyun Wang Tao Wang 
supported by the National Science Foundation of China (31270201);the National Key Research and Development Program of China (2017YFA0205102);the Seed Foundation of Tianjin University (2014XRX-0026);the National Science Foundation of Tianjin (No.16JCQNJC09800)
Severe fever with thrombocytopenia syndrome(SFTS)is an emerging hemorrhagic fever disease caused by SFTSV,a newly discovered phlebovirus that is named after the disease.Currently,no effective vaccines or drugs are ava...
关键词：BORTEZOMIB PS-341 Severe fever with thrombocytopenia syndrome virus(SFTSV) IFN-Β Apoptosis 
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