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L-ASP: 作品数：72被引量：112H指数：5; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：顾龙君陈静韦菊英江华潘慈更多>>; 相关机构：中山大学上海第二医科大学附属新华医院广州医学院第一附属医院嘉兴市第一医院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划Problem Solving for Better Health辽宁省自然科学基金更多>>

Synthesis and molecular recognition characteristics of a tetrapodal benzene cage: 《Chinese Chemical Letters》2024年第8期240-244,共5页Caihong Mao Yanfeng He Xiaohan Wang Yan Cai Xiaobo Hu; support by the National Natural Science Foundation of China(No.22101260);Natural Science Foundation of Zhejiang Province(No.LQ22B020001).; In this contribution,we describe the preparation and recognition characteristics of a novel tetrapodal benzene cage(1).The cage can express a wide recognition range without losing selectivity for the object of appropr...; 关键词：Cage molecules Host-guest chemistry Multi-step organic synthesis d-Lactate recognition l-Asp recognition

Therapeutic Effect of Prolyl Endopeptidase Inhibitor in High-fat Diet-induced Metabolic Dysfunction-associated Fatty Liver Disease: 《Journal of Clinical and Translational Hepatology》2023年第5期1035-1049,共15页Jian-Bin Zhang Meng-Ting Li Shuang-Zhe Lin Yu-Qing Cheng Jian-Gao Fan Yuan-Wen Chen; supported by grants from the National Natural Science Foundation of China(81970511,82270620).; Background and Aims:Prolyl endopeptidase(PREP)is a serine endopeptidase that participates in many pathological processes including inflammation,oxidative stress,and autophagy.Our previous studies found that PREP knock...; 关键词：Metabolic dysfunction-associated fatty liver disease Prolyl endopeptidase KYP-2047 Proline-glycine-proline N-acetyl-seryl-aspartyl-lysylproline

PEG-Asp、L-Asp治疗儿童急性淋巴细胞白血病的疗效及对患儿凝血功能的影响: 《实验与检验医学》2023年第3期297-299,303,共4页王见涛杜永光王璐戴振霞李玉霞张红梅; 目的探讨培门冬酶(PEG-Asp)与左旋门冬酰胺酶(L-Asp)对儿童急性淋巴细胞白血病(ALL)患者凝血功能的影响。方法选取我院2018年6月至2021年6月收治的急性淋巴细胞白血病患儿123例,根据治疗方法不同分为PEG-Asp组(51例)和L-Asp组(72例)。...; 关键词：儿童急性淋巴细胞白血病培门冬酶左旋门冬酰胺酶凝血功能

Endovascular therapy in acute anterior circulation large vessel occlusive patients with a large infarct core(ANGEL-ASPECT):protocol of a multicentre randomised trial被引量：1: 《Stroke & Vascular Neurology》2023年第2期169-174,共6页Xiaochuan Huo Gaoting Ma Xuelei Zhang Yuesong Pan Xu Tong Dapeng Sun Liping Liu Yilong Wang David S Liebeskind Yongjun Wang Vitor Mendes Pereira Zeguang Ren Zhongrong Miao; Background The benefit of stroke thrombectomy for large infarct core still lacks robust randomised controlled studies.Aim To demonstrate the design of a clinical trial on endovascular therapy for acute anterior circul...; 关键词：PATIENTS INFARCT ACUTE

ANGEL-ASPECT:大梗死核心急性缺血性卒中血管内治疗的中国方案: 《中国卒中杂志》2023年第3期247-249,共3页吴川杰吉训明; 卒中是世界各国的主要致死和致残性疾病,我国的卒中防控形势尤为严峻,我国成人卒中终身患病风险高达39.3%,居世界首位[1]。约1/3的急性缺血性卒中是由于颅内大血管急性闭塞所致,这类卒中患者临床症状重、预后差,是卒中临床救治的关键。; 关键词：缺血性卒中大梗死核心梗死核心体积血管内治疗

Evidence-based approach to management of hepatic encephalopathy in adults: 《World Journal of Hepatology》2022年第4期670-681,共12页Gilles Jadd Hoilat Fathima Keshia Suhail Talal Adhami Savio John; Hepatic encephalopathy(HE)is a reversible syndrome of impaired brain function and represents one of the many complications of portal hypertension and decompensated liver disease.Although ammonia is clearly implicated ...; 关键词：Hepatic encephalopathy LACTULOSE RIFAXIMIN Fecal microbiota transplant Zinc L-ornithine L-aspartate

Isolation and mechanism analysis of a catalytic efciency improved L‑aspartateβ‑decarboxylase toward 3‑methylaspartic acid被引量：1: 《Systems Microbiology and Biomanufacturing》2022年第1期157-164,共8页Yufeng Liu Mingzhu Hao Zhemin Zhou Zhongmei Liu; This work was supported by National Key R&D Program of China(2017YFE0129600);the National Natural Science Foundation of China(21878125);the Priority Academic Program Development of Jiangsu Higher Education Institutions,the 111 Project(No.111-2-06).; L-Aspartateβ-decarboxylase from Acinetobacter radioresistens(ArASD)has been modifed to convert 3-methylaspartic acid into 2-aminobutyric acid,which activated a novel process for biosynthesis of 2-aminobutyric acid.Ho...; 关键词：L-Aspartateβ-decarboxylase 3-Methylasparic acid The internal aldimine Enzyme engineering Molecular dynamics simulation

Development of a dual-fluorescence reporter system for high-throughput screening of L-aspartate-a-decarboxylase: 《Acta Biochimica et Biophysica Sinica》2020年第12期1420-1426,共7页Mingyue Fei Xudan Mao Yiyang Chen Yalan Lu Lin Wang Jie Yang Juanping Qiu Dongchang Sun; supported by the grants from the Key Research and Development Program of Zhejiang Province(No.2020C02031);the Zhejiang Provincial Natural Science Foundation of China(No.L.Y16C010003);the National Natural Science Foundation of China(No.31670084).; β-Alanine (3-am inopropionic acid)holds great potential in industrial application.It can be obtained through a chemical synthesis route,which is hazardous to the environm ent.It is w ell known that L-aspartate-a-deca...; 关键词：L-aspartate-a-decarboxylase Β-ALANINE site-mutagenesis

探讨左旋门冬酰胺酶(L-ASP)治疗白血病患儿对凝血功能的影响: 《首都食品与医药》2019年第17期40-40,共1页史利欢陈静谢昕; 目的探讨左旋门冬酰胺酶对急性淋巴细胞白血病患儿凝血功能的影响情况。方法对照组予以常规化疗方案,研究组在对照组治疗基础上加用左旋门冬酰胺酶。结果两组治疗前APTT、PT、TT、Fbg等指标检测值对比P>0.05;用药期间研究组APTT、PT、T...; 关键词：白血病左旋门冬酰胺酶凝血功能影响情况

Peg-asp与L-asp治疗儿童初发急性淋巴细胞白血病的安全性评估被引量：6: 《基因组学与应用生物学》2018年第11期5006-5011,共6页郝琴贺智英; 延安大学医学院内儿护理学教研室资助; 培门冬酶（Peg-asp）与左旋门冬酰胺酶（L-asp）是治疗急性淋巴细胞白血病（ALL）的常用药物。为评估Peg-asp与L-asp在治疗儿童初发急性淋巴细胞白血病的安全性以及为这两种制剂的临床应用提供合理的参考依据，本研究选取初发ALL患儿，...; 关键词：左旋门冬酰胺酶安全性培门冬酶急性淋巴细胞白血病

L-ASP