MELANOPSIN

作品数:13被引量:62H指数:4
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相关领域:医药卫生更多>>
相关作者:肖虹蕾周国民武静刘丽芸周晓东更多>>
相关机构:复旦大学上海医学院复旦大学第三军医大学第一附属医院第三军医大学西南眼科医院更多>>
相关期刊:《International Journal of Ophthalmology(English edition)》《Chinese Medical Journal》《浙江海洋大学学报(自然科学版)》《Neural Regeneration Research》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划上海市卫生局资助项目更多>>
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光谱对小黄鱼胚胎在孵化、关键免疫因子水平及感光和节律基因表达的影响分析
《浙江海洋大学学报(自然科学版)》2022年第3期211-220,共10页李沪 韩明明 詹炜 刘峰 谢庆平 徐万土 楼宝 
浙江省农业科学院学科项目建设经费(10419000021CC2201G);国家重点研发计划“蓝色粮仓科技创新”重点专项(2018YFD0901204);浙江省重点研发计划(2021C02055)。
通过比较6种光谱环境(自然光、红光、绿光、蓝光、白光、黑暗)下小黄鱼胚胎的孵化率、孵化时长和主要免疫因子的含量及初孵仔鱼中melanopsin和clock基因的表达,发现:(1)红光组胚胎孵化率最高(49.56%),其次为黑暗组(38.66%)、全光组(31.4...
关键词:光谱 小黄鱼 孵化率 孵化时长 免疫因子 MELANOPSIN CLOCK 
Photophobia in neurologic disorders被引量:1
《Translational Neurodegeneration》2017年第1期239-244,共6页Yiwen Wu Mark Hallett 
The work was supported by the National Natural Science Foundation of China(No.81200981,81,371,407);the Innovation Program of Shanghai Municipal Education Commission(No.13YZ026);the Intramural Program of the National Institute of Neurological Disorders and Stroke.
Photophobia is a common symptom seen in many neurologic disorders,however,its pathophysiology remains unclear.Even the term is ambiguous.In this paper,we review the epidemiology and clinical manifestations of photopho...
关键词:PHOTOPHOBIA MIGRAINE BLEPHAROSPASM Progressive supranuclear palsy Traumatic brain injury MELANOPSIN 
Professor Russell Foster:melanopsin signalling to the molecular clockwork
《Annals of Eye Science》2017年第1期329-330,共2页Nikki Ling Elaine Xu 
Expert introduction Dr.Russell Foster(Figure 1)is the professor of Nuffield Laboratory of Ophthalmology,Head of the Nuffield Laboratory of Ophthalmology and the Sleep and Circadian Neuroscience Institute.Prior to this...
关键词:RUSSELL FOSTER FIGURE 
Melanopsin expression is an indicator of the well-being of melanopsin-expressing retinal ganglion cells but not of their viability被引量:1
《Neural Regeneration Research》2016年第8期1243-1244,共2页Marta Agudo-Barriuso Francisco M.Nadal-Nicolás María H.Madeira Giuseppe Rovere Beatriz Vidal-Villegas Manuel Vidal-Sanz 
supported by the Spanish Ministry of Education and Science SAF2015-67643-P;Spanish Ministry of Economy and Competitiveness ISCIII-FEDER “Una manera de hacer Europa” PI13/00643
Light is an electromagnetic stimulus that in mammals is sensed by specialized neurons in the retina.The physiological response to light encompasses two fundamental and different functional outputs:image-forming and n...
关键词:RGCs retina specialized physiological expressing ganglion viability tracing Figure unpublished 
Human melanopsin-AAV2/8 transfection to retina transiently restores visual function in rd1 mice被引量:4
《International Journal of Ophthalmology(English edition)》2016年第5期655-661,共7页Ming-Ming Liu Jia-Man Dai Wen-Yi Liu Cong-Jian Zhao Bin Lin Zheng-Qin Yin 
Supported by the Chongqing Internationa Cooperation Key Projects(No.CSTC2013GJHZ10004);National Basic Research Program of China(973 Program No.2013CB967002)
AIM: To explore whether ectopic expression of human melanopsin can effectively and safely restore visual function in rd1 mice.· METHODS: Hematoxylin-eosin staining of retinal sections from rd1 mice was used to dete...
关键词:human melanopsin retinal degenerative diseases visual restoration 
Melanopsin-expressing retinal ganglion cell loss and behavioral analysis in the Thy1-CFP-DBA/2J mouse model of glaucoma被引量:4
《Science China(Life Sciences)》2013年第8期720-730,共11页ZHANG Qi VUONG Helen HUANG Xin WANG YanLing BRECHA Nicholas C. PU MingLiang GAO Jie 
supported by the National Basic Research Program of China (2009CB320900 to Pu MingLiang,2011CB510206 to Pu MingLiangand Gao Jie);National Natural Science Foundation of China(30831160516 to Pu MingLiang);NIH EY04067 (N.C. Brecha);VAMerit Review (N.C. Brecha).;supported by a summer fellowship from the PKU-UCLA Joint Research Institute
In this study, the role of melanopsin-expressing retinal ganglion cells (mRGCs) in the glaucoma-induced depressive behavioral response pattern was investigated. The CFP-D2 transgenic glaucoma animal model from five ...
关键词:pigmentary glaucoma Thyl-CFP-DBA/2J mouse retinal ganglion cells melanopsin-expressing retinal ganglion cells depression 
青光眼小鼠Thy1-CFP-DBA/2J表达melanopsin蛋白的视网膜节细胞的丢失及小鼠行为学分析
《中国科学:生命科学》2013年第8期631-642,共12页张琦 VUONG Helen 黄鑫 王艳玲 BRECHA Nicholas Conrad 濮鸣亮 高洁 
国家重点基础研究发展计划(批准号:2009CB320900,2011CB510206);国家自然科学基金重点项目(批准号:30831160516);NIH(批准号:EY04067);VA Merit Review资助
为了研究表达melanopsin蛋白的视网膜神经节细胞在青光眼小鼠的抑郁性行为中所起的作用,本文使用不同年龄的青光眼小鼠Thy1-CFP-DBA/2J(CFP-D2)2,5,8,11,14个月龄各5只,对照组为C57BL/6小鼠2,8,14个月龄各5只.对视网膜平铺片进行免疫组...
关键词:青光眼 Thyl—CFP—DBA 2J小鼠 RGC mRGC 抑郁 
昼夜节律的改变对视网膜感光视蛋白melanopsin表达的影响被引量:3
《中国实验动物学报》2012年第2期70-73,I0006,共5页武静 周晓东 刘丽芸 周国民 肖虹蕾 
上海市卫生局项目(编号:2007010)
目的研究昼夜节律的改变对视网膜感光视蛋白melanopsin表达的影响。方法出生14 d(P14)C57BL/6J小鼠随机分为实验组和正常对照组,实验组每天给予24 h持续光照,对照组模拟正常昼夜节律每天给予12 h光照、12 h黑暗环境,运用免疫荧光染色结...
关键词:昼夜节律 视网膜神经节细胞 光感受作用 MELANOPSIN 小鼠 
Intrinsically photosensitive retinal ganglion cells被引量:18
《Science China(Life Sciences)》2010年第1期58-67,共10页Gary E.PICKARD Patricia J.SOLLARS 
supported by grants from the National Institutes of Health, the National Institute of Neurological Disorders and Stroke R01 NS035615;the National Eye Institute R01 EY017809
A new mammalian photoreceptor was recently discovered to reside in the ganglion cell layer of the inner retina.These intrinsically photosensitive retinal ganglion cells(ipRGCs) express a photopigment,melanopsin,that c...
关键词:MELANOPSIN CIRCADIAN RHYTHMS SUPRACHIASMATIC nucleus retina pupillary light REFLEX 
提前光刺激对小鼠神经节细胞感光视蛋白melanopsin表达的影响被引量:4
《眼视光学杂志》2008年第3期190-193,共4页武静 周晓东 周国民 刘丽芸 肖虹蕾 
上海市卫生局资助项目(2007010)
目的探讨提前光刺激对小鼠神经节细胞发育不同阶段感光视蛋白melanopsin表达的影响。方法对出生4dC57BL/6J小鼠右眼建立提前开睑接受光刺激模型,左眼作为自身对照,应用免疫荧光、RT-PCR和Western blotting方法比较小鼠5天龄、6天龄、7...
关键词:神经节细胞 光感受作用 发育 MELANOPSIN 
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