supported by the National Natural Science Foundation of China(No.31171104 and 30670772);the Key Program of Scientific Research of Fujian Medical University;China(No.09ZD010)
supported by the Science Research Foundation of Ministry of Health of China-Pharmaceutical and Health Care Science and Technology Major Program of Zhejiang Province,China(No.WKJ2009-2-030);Traditional Chinese Medicine Key Discipline Construction Project of Zhejiang Province,China(No.2012-XK-A28)