肿瘤相关成纤维细胞在食管鳞癌中作用的研究进展  

Progress in the role of tumor-associated fibroblasts in esophageal squamous cell carcinoma

作　　者：张倩[1] 梁亚冰 杨凌[2] ZHANG Qian;LIANG Yabing;YANG Ling(Graduate School of Inner Mongolia Medical University,Key Laboratory of Medical Cell Biology in Mongolia Autonomous Region,Hohhot 010110,Mongolia Autonomous Region,China;Clinical Medical Research Center of Inner Mongolia Medical University Affiliated Hospital,Key Laboratory of Medical Cell Biology in Mongolia Autonomous Region,Hohhot 010050,Mongolia Autonomous Region,China)

机构地区：[1]内蒙古医科大学研究生院,内蒙古自治区医学细胞生物学重点实验室,内蒙古自治区呼和浩特010110 [2]内蒙古医科大学附属医院临床医学研究中心,内蒙古自治区医学细胞生物学重点实验室,内蒙古呼和浩特010050

出　　处：《肿瘤》2022年第4期295-304,共10页Tumor

基　　金：国家自然科学基金(31960153);内蒙古自然科学基金(2021LHMS08041)

摘　　要：食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)是食管癌(esophageal cancer,EC)的一种,具有恶性程度高、预后差的特点。除了癌细胞,由一系列驻留和招募的细胞以及细胞外基质构成的肿瘤微环境(tumor microenvironment,TME)也是导致其难以攻克的原因之一。肿瘤相关成纤维细胞(cancer-associated fibroblasts,CAFs)是存在于肿瘤微环境中的一类重要细胞群。CAFs通过多种细胞因子,如白血病抑制因子(leukemia inhibitory factor,LIF)、白细胞介素6(interleukin-6,IL-6)、IL-8和C-C基序趋化因子配体2(C-C motif chemokine ligand 2,CCL2)等获得激活的表型,分泌可溶性分子,重塑细胞外基质,促进肿瘤细胞的增殖和生长,加速肿瘤细胞的侵袭和转移,诱导肿瘤细胞对免疫的耐受和对化疗的耐药性。目前认为,CAFs在ESCC的治疗和预后判断方面扮演着重要角色,因此更好地了解CAFs对ESCC的主要影响及分子机制,将有助于寻找更有价值的治疗靶点,以及更有效地指导临床实践。Esophageal squamous cell carcinoma(ESCC)is a type of esophageal cancer(EC)and one of the most lethal malignant tumors with poor prognosis.In addition to cancer cells,the tumor microenvironment(TME),which consists of a series of resident cells,recruited cells and extracellular matrix,is also one of the reasons for its intractability.Cancer-associated fibroblasts(CAFs)are an important group of cells existing in the tumor microenvironment.CAFs acquire an activated phenotype through binding with various cytokines such as leukemia inhibitory factor(LIF),interleukin-6(IL-6),IL-8,C-C motif chemokine ligand 2(CCL2),etc.,secrete soluble molecules,remodel the extracellular matrix,promote tumor proliferation and growth,accelerate tumor invasion and metastasis,and induce tumor tolerance to immunity and resistance to chemotherapy.Currently,CAFs are believed to play important roles in the treatment and prognosis prediction of ES.Therefore,a better understanding of the major effects of CAFs on ESCC and the underlying molecular mechanisms will help to find more valuable therapeutic targets and guide clinical practice more effectively.

关 键 词：食管鳞状细胞癌 肿瘤微环境 肿瘤相关成纤维细胞 

分 类 号：R735.1[医药卫生—肿瘤]